The association between bone turnover markers and kyphosis in community-dwelling older adults
Purpose: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-12-01
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| Series: | Bone Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187216300122 |
| _version_ | 1819086861050576896 |
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| author | Corinne R. McDaniels-Davidson Donna Kritz-Silverstein Mei-Hua Huang Gail A. Laughlin Sarah Johnson Jouko Haapalahti Diane L. Schneider Elizabeth Barrett-Connor Deborah M. Kado |
| author_facet | Corinne R. McDaniels-Davidson Donna Kritz-Silverstein Mei-Hua Huang Gail A. Laughlin Sarah Johnson Jouko Haapalahti Diane L. Schneider Elizabeth Barrett-Connor Deborah M. Kado |
| author_sort | Corinne R. McDaniels-Davidson |
| collection | DOAJ |
| description | Purpose: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. Methods: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured. Fasting serum was assayed for N-telopeptide (NTX) and procollagen type 1 n-terminal propeptide (P1NP), markers of bone resorption and formation, respectively. Participants requiring two or more 1.7 cm blocks under their head to achieve a neutral supine position were classified as having accentuated kyphosis. Analyses were stratified by sex and use of estrogen therapy (ET). Odds of accentuated kyphosis were calculated for each standard deviation increase in log-transformed BTM. Results: Mean age was 75 years. Overall, 51% of 341 non-ET using women, 41% of 111 ET-using women, and 75% of 308 men had accentuated kyphosis. In adjusted models, higher P1NP and NTX were associated with decreased odds of accentuated kyphosis in non-ET using women (P1NP: OR = 0.78 [95% CI, 0.58–0.92]; NTX: OR = 0.68 [95% CI, 0.54–0.86]), but not in men or ET-using women (p > 0.05). Conclusions: The selective association of higher bone turnover with reduced odds of accentuated kyphosis in non-ET using women suggests that elevated BTM were associated with a lower likelihood of hyperkyphosis only in the low estrogen/high BTM environment characteristic of postmenopausal women who are not using ET. Keywords: Kyphosis, Hyperkyphosis, Bone turnover, Bone remodeling, P1NP, NTX |
| first_indexed | 2024-12-21T21:26:58Z |
| format | Article |
| id | doaj.art-b243b0a22fbb4ab090da85cefb57f247 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-21T21:26:58Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-b243b0a22fbb4ab090da85cefb57f2472022-12-21T18:49:44ZengElsevierBone Reports2352-18722016-12-0155761The association between bone turnover markers and kyphosis in community-dwelling older adultsCorinne R. McDaniels-Davidson0Donna Kritz-Silverstein1Mei-Hua Huang2Gail A. Laughlin3Sarah Johnson4Jouko Haapalahti5Diane L. Schneider6Elizabeth Barrett-Connor7Deborah M. Kado8San Diego State University/University of California, San Diego Joint Doctoral Program in Public Health (Epidemiology), 9500 Gilman Drive, MC 0725, La Jolla, CA 92093, United States; Corresponding author.Department of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United StatesDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United StatesDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United StatesSPD Development Company Limited, Bedford, UKJouZeNet Consulting Limited, Kempele, Finland4BoneHealth, La Jolla, CA, United StatesDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United StatesDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United StatesPurpose: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. Methods: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured. Fasting serum was assayed for N-telopeptide (NTX) and procollagen type 1 n-terminal propeptide (P1NP), markers of bone resorption and formation, respectively. Participants requiring two or more 1.7 cm blocks under their head to achieve a neutral supine position were classified as having accentuated kyphosis. Analyses were stratified by sex and use of estrogen therapy (ET). Odds of accentuated kyphosis were calculated for each standard deviation increase in log-transformed BTM. Results: Mean age was 75 years. Overall, 51% of 341 non-ET using women, 41% of 111 ET-using women, and 75% of 308 men had accentuated kyphosis. In adjusted models, higher P1NP and NTX were associated with decreased odds of accentuated kyphosis in non-ET using women (P1NP: OR = 0.78 [95% CI, 0.58–0.92]; NTX: OR = 0.68 [95% CI, 0.54–0.86]), but not in men or ET-using women (p > 0.05). Conclusions: The selective association of higher bone turnover with reduced odds of accentuated kyphosis in non-ET using women suggests that elevated BTM were associated with a lower likelihood of hyperkyphosis only in the low estrogen/high BTM environment characteristic of postmenopausal women who are not using ET. Keywords: Kyphosis, Hyperkyphosis, Bone turnover, Bone remodeling, P1NP, NTXhttp://www.sciencedirect.com/science/article/pii/S2352187216300122 |
| spellingShingle | Corinne R. McDaniels-Davidson Donna Kritz-Silverstein Mei-Hua Huang Gail A. Laughlin Sarah Johnson Jouko Haapalahti Diane L. Schneider Elizabeth Barrett-Connor Deborah M. Kado The association between bone turnover markers and kyphosis in community-dwelling older adults Bone Reports |
| title | The association between bone turnover markers and kyphosis in community-dwelling older adults |
| title_full | The association between bone turnover markers and kyphosis in community-dwelling older adults |
| title_fullStr | The association between bone turnover markers and kyphosis in community-dwelling older adults |
| title_full_unstemmed | The association between bone turnover markers and kyphosis in community-dwelling older adults |
| title_short | The association between bone turnover markers and kyphosis in community-dwelling older adults |
| title_sort | association between bone turnover markers and kyphosis in community dwelling older adults |
| url | http://www.sciencedirect.com/science/article/pii/S2352187216300122 |
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