Human androgen deficiency: insights gained from androgen receptor knockout mouse models
The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models. A number of global and tissue-specific AR knockout (ARKO) models have been gener...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-04-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=169;epage=177;aulast=Rana |
| _version_ | 1819133898614898688 |
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| author | Kesha Rana Rachel A Davey Jeffrey D Zajac |
| author_facet | Kesha Rana Rachel A Davey Jeffrey D Zajac |
| author_sort | Kesha Rana |
| collection | DOAJ |
| description | The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models. A number of global and tissue-specific AR knockout (ARKO) models have been generated using the Cre-loxP system which allows tissue- and/or cell-specific deletion. These ARKO models have examined a number of sites of androgen action including the cardiovascular system, the immune and hemopoetic system, bone, muscle, adipose tissue, the prostate and the brain. This review focuses on the insights that have been gained into human androgen deficiency through the use of ARKO mouse models at each of these sites of action, and highlights the strengths and limitations of these Cre-loxP mouse models that should be considered to ensure accurate interpretation of the phenotype. |
| first_indexed | 2024-12-22T09:54:37Z |
| format | Article |
| id | doaj.art-b246568227cc4115be2e8c901384b5c3 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-22T09:54:37Z |
| publishDate | 2014-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-b246568227cc4115be2e8c901384b5c32022-12-21T18:30:19ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622014-04-0116216917710.4103/1008-682X.122590Human androgen deficiency: insights gained from androgen receptor knockout mouse modelsKesha RanaRachel A DaveyJeffrey D ZajacThe mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models. A number of global and tissue-specific AR knockout (ARKO) models have been generated using the Cre-loxP system which allows tissue- and/or cell-specific deletion. These ARKO models have examined a number of sites of androgen action including the cardiovascular system, the immune and hemopoetic system, bone, muscle, adipose tissue, the prostate and the brain. This review focuses on the insights that have been gained into human androgen deficiency through the use of ARKO mouse models at each of these sites of action, and highlights the strengths and limitations of these Cre-loxP mouse models that should be considered to ensure accurate interpretation of the phenotype.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=169;epage=177;aulast=Ranaandrogen receptor; androgen receptor knockout mouse model; androgen deficiency |
| spellingShingle | Kesha Rana Rachel A Davey Jeffrey D Zajac Human androgen deficiency: insights gained from androgen receptor knockout mouse models Asian Journal of Andrology androgen receptor; androgen receptor knockout mouse model; androgen deficiency |
| title | Human androgen deficiency: insights gained from androgen receptor knockout mouse models |
| title_full | Human androgen deficiency: insights gained from androgen receptor knockout mouse models |
| title_fullStr | Human androgen deficiency: insights gained from androgen receptor knockout mouse models |
| title_full_unstemmed | Human androgen deficiency: insights gained from androgen receptor knockout mouse models |
| title_short | Human androgen deficiency: insights gained from androgen receptor knockout mouse models |
| title_sort | human androgen deficiency insights gained from androgen receptor knockout mouse models |
| topic | androgen receptor; androgen receptor knockout mouse model; androgen deficiency |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=169;epage=177;aulast=Rana |
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