PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis
The aim of our prospective study was to evaluate the clinical impact of hybrid [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([<sup>18</sup>F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclin...
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| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/949 |
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| author | Katalin Borbély Miklós Emri István Kenessey Márton Tóth Júlia Singer Péter Barsi Zsolt Vajda Endre Pál Zoltán Tóth Thomas Beyer Tamás Dóczi Gábor Bajzik Dániel Fabó József Janszky Zsófia Jordán Dániel Fajtai Anna Kelemen Vera Juhos Max Wintermark Ferenc Nagy Mariann Moizs Dávid Nagy János Lückl Imre Repa |
| author_facet | Katalin Borbély Miklós Emri István Kenessey Márton Tóth Júlia Singer Péter Barsi Zsolt Vajda Endre Pál Zoltán Tóth Thomas Beyer Tamás Dóczi Gábor Bajzik Dániel Fabó József Janszky Zsófia Jordán Dániel Fajtai Anna Kelemen Vera Juhos Max Wintermark Ferenc Nagy Mariann Moizs Dávid Nagy János Lückl Imre Repa |
| author_sort | Katalin Borbély |
| collection | DOAJ |
| description | The aim of our prospective study was to evaluate the clinical impact of hybrid [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([<sup>18</sup>F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classification of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclinical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of “invasive” (operable and implantable) and “not eligible for any further invasive procedures” groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data. |
| first_indexed | 2024-03-10T03:18:41Z |
| format | Article |
| id | doaj.art-b246b1d71d4c46189fb6e9edbc151ea3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:18:41Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b246b1d71d4c46189fb6e9edbc151ea32023-11-23T10:08:51ZengMDPI AGBiomedicines2227-90592022-04-0110594910.3390/biomedicines10050949PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance AnalysisKatalin Borbély0Miklós Emri1István Kenessey2Márton Tóth3Júlia Singer4Péter Barsi5Zsolt Vajda6Endre Pál7Zoltán Tóth8Thomas Beyer9Tamás Dóczi10Gábor Bajzik11Dániel Fabó12József Janszky13Zsófia Jordán14Dániel Fajtai15Anna Kelemen16Vera Juhos17Max Wintermark18Ferenc Nagy19Mariann Moizs20Dávid Nagy21János Lückl22Imre Repa23PET/CT Outpatient Department, National Institute of Oncology, H1122 Budapest, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryNational Cancer Registry, National Institute of Oncology, H1122 Budapest, HungaryDepartment of Neurology, Medical School, University of Pécs, H7623 Pécs, HungaryAccelsiors Ltd., H1222 Budapest, HungaryNeuroradiology Department, Semmelweis University, H1083 Budapest, HungaryDr. József Baka Diagnostic, Radiation Oncology, Research and Teaching Center, Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryDepartment of Pathology, Medical School, University of Pécs, H7623 Pécs, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryQIMP Team, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Neurosurgery, Medical School, University of Pécs, H7623 Pécs, HungaryDr. József Baka Diagnostic, Radiation Oncology, Research and Teaching Center, Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryDepartment of Neurology and Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, H1145 Budapest, HungaryDepartment of Neurology, Medical School, University of Pécs, H7623 Pécs, HungaryDepartment of Neurology and Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, H1145 Budapest, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryDepartment of Neurology and Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, H1145 Budapest, HungaryEpihope Non-Profit Kft, H1026 Budapest, HungaryDepartment of Neuroradiology, MD Anderson, Houston, TX 77030, USADepartment of Neurology, Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryDepartment of Neurology and Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, H1145 Budapest, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryMedicopus Healthcare Provider and Public Nonprofit Ltd., Somogy County Moritz Kaposi Teaching Hospital, H7400 Kaposvár, HungaryThe aim of our prospective study was to evaluate the clinical impact of hybrid [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([<sup>18</sup>F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classification of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclinical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of “invasive” (operable and implantable) and “not eligible for any further invasive procedures” groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data.https://www.mdpi.com/2227-9059/10/5/949epilepsy surgerymedically refractory focal epilepsypresurgical evaluationMRI-negative patientsdiscordant electroclinical and MRI datametabolic PET |
| spellingShingle | Katalin Borbély Miklós Emri István Kenessey Márton Tóth Júlia Singer Péter Barsi Zsolt Vajda Endre Pál Zoltán Tóth Thomas Beyer Tamás Dóczi Gábor Bajzik Dániel Fabó József Janszky Zsófia Jordán Dániel Fajtai Anna Kelemen Vera Juhos Max Wintermark Ferenc Nagy Mariann Moizs Dávid Nagy János Lückl Imre Repa PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis Biomedicines epilepsy surgery medically refractory focal epilepsy presurgical evaluation MRI-negative patients discordant electroclinical and MRI data metabolic PET |
| title | PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis |
| title_full | PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis |
| title_fullStr | PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis |
| title_full_unstemmed | PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis |
| title_short | PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis |
| title_sort | pet mri in the presurgical evaluation of patients with epilepsy a concordance analysis |
| topic | epilepsy surgery medically refractory focal epilepsy presurgical evaluation MRI-negative patients discordant electroclinical and MRI data metabolic PET |
| url | https://www.mdpi.com/2227-9059/10/5/949 |
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