To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood
Background: In many nations, low Vitamin D levels in pregnant women have been associated to adverse outcomes for the mother, her baby, and the birth itself. Aims and Objectives: To study the effect of oral supplementation of mothers with high dose vitamin D (2000IU/day) in comparison with mainten...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-09-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/45296 |
| _version_ | 1818014299066466304 |
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| author | Sravanthi Veldanadi Kavitha Vislavath Archana Challa Praveen Dussa Vasudeva Murali |
| author_facet | Sravanthi Veldanadi Kavitha Vislavath Archana Challa Praveen Dussa Vasudeva Murali |
| author_sort | Sravanthi Veldanadi |
| collection | DOAJ |
| description | Background: In many nations, low Vitamin D levels in pregnant women have been associated to adverse outcomes for the mother, her baby, and the birth itself.
Aims and Objectives: To study the effect of oral supplementation of mothers with high dose vitamin D (2000IU/day) in comparison with maintenance dose (400IU/day) during pregnancy on vitamin D status of cord blood at the time of delivery.
Materials and Methods: Randomized single blind controlled trial conducted in 112 mothers recruited in first trimester, randomized into two groups. One group of mothers received 2000 IU/day, one group 400 IU/day till delivery. Mothers are followed up till delivery age, weight, height, and dressing.
Results: Vitamin D levels in mothers in study group were showing 88% insufficiency (<20 ng/ml) and 12% sufficiency (>20 ng/ml). Mean values in both groups that is Group A 6.6±2.8, in Group B 6.2±2.2, both means are comparable with P=0.47, but after supplementation mean maternal Vitamin D level that is 13.4±3.6, with P≤0.0001, this shows that there is a statistically significant. There is a statistically significant correlation is observed between maternal and cord blood Vitamin D levels after supplementation. Statistically significant correlation was observed between maternal and cord blood Vitamin D levels.
Conclusions: Vitamin D supplementation throughout pregnancy enhances maternal serum and Vitamin D levels at term, according to this study. There is currently sufficient high-quality evidence pertaining to the therapeutic effects of Vitamin D supplementation during pregnancy. |
| first_indexed | 2024-04-14T06:43:13Z |
| format | Article |
| id | doaj.art-b24a7973e4f94e4795fe1a1ad51150a9 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-14T06:43:13Z |
| publishDate | 2022-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-b24a7973e4f94e4795fe1a1ad51150a92022-12-22T02:07:15ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-09-01139117124https://doi.org/10.3126/ajms.v13i9.45296To study the effect of oral supplementation Vitamin D during pregnancy and status of cord bloodSravanthi Veldanadi 0https://orcid.org/0000-0003-2732-6273Kavitha Vislavath 1https://orcid.org/0000-0003-0878-1174Archana Challa 2https://orcid.org/0000-0003-1929-4611Praveen Dussa 3https://orcid.org/0000-0003-0280-2309Vasudeva Murali 4https://orcid.org/0000-0002-9514-7181Assistant Professor, Department of Pediatrics, Niloufer Hospital for Women and Children/Osmania Medical College, Koti, Hyderabad, India Assistant Professor, Department of Pediatrics, Niloufer Hospital for Women and Children/Osmania Medical College, Koti, Hyderabad, India Assistant Professor, Department of Pediatrics, Niloufer Hospital for Women and Children/Osmania Medical College, Koti, Hyderabad, India Assistant Professor, Department of Orthopaedics Osmania Medical College, Koti, Hyderabad, Telangana, India Professor, Department of Pediatrics, Nizamabad Medical College, Nizamabad, Telangana, India Background: In many nations, low Vitamin D levels in pregnant women have been associated to adverse outcomes for the mother, her baby, and the birth itself. Aims and Objectives: To study the effect of oral supplementation of mothers with high dose vitamin D (2000IU/day) in comparison with maintenance dose (400IU/day) during pregnancy on vitamin D status of cord blood at the time of delivery. Materials and Methods: Randomized single blind controlled trial conducted in 112 mothers recruited in first trimester, randomized into two groups. One group of mothers received 2000 IU/day, one group 400 IU/day till delivery. Mothers are followed up till delivery age, weight, height, and dressing. Results: Vitamin D levels in mothers in study group were showing 88% insufficiency (<20 ng/ml) and 12% sufficiency (>20 ng/ml). Mean values in both groups that is Group A 6.6±2.8, in Group B 6.2±2.2, both means are comparable with P=0.47, but after supplementation mean maternal Vitamin D level that is 13.4±3.6, with P≤0.0001, this shows that there is a statistically significant. There is a statistically significant correlation is observed between maternal and cord blood Vitamin D levels after supplementation. Statistically significant correlation was observed between maternal and cord blood Vitamin D levels. Conclusions: Vitamin D supplementation throughout pregnancy enhances maternal serum and Vitamin D levels at term, according to this study. There is currently sufficient high-quality evidence pertaining to the therapeutic effects of Vitamin D supplementation during pregnancy.https://www.nepjol.info/index.php/AJMS/article/view/45296vitamin d; cord blood; oral supplementation |
| spellingShingle | Sravanthi Veldanadi Kavitha Vislavath Archana Challa Praveen Dussa Vasudeva Murali To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood Asian Journal of Medical Sciences vitamin d; cord blood; oral supplementation |
| title | To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood |
| title_full | To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood |
| title_fullStr | To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood |
| title_full_unstemmed | To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood |
| title_short | To study the effect of oral supplementation Vitamin D during pregnancy and status of cord blood |
| title_sort | to study the effect of oral supplementation vitamin d during pregnancy and status of cord blood |
| topic | vitamin d; cord blood; oral supplementation |
| url | https://www.nepjol.info/index.php/AJMS/article/view/45296 |
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