Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)

Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)

Abstract Background Cell-free DNA (cfDNA) contains a large amount of molecular information that can be used for multi-cancer early detection (MCED), including changes in epigenetic status of cfDNA, such as cfDNA fragmentation profile. The fragmentation of cfDNA is non-random and may be related to cf...

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Bibliographic Details
Main Authors: Pin Cui, Xiaozhou Zhou, Shu Xu, Weihuang He, Guozeng Huang, Yong Xiong, Chuxin Zhang, Tingmin Chang, Mingji Feng, Hanming Lai, Yi Pan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Clinical Epigenetics
Subjects:
Methylation status
Multi-cancer early detection
WGS
WGBS
cfDNA fragmentation profile
Online Access:https://doi.org/10.1186/s13148-024-01646-6

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