Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair
The foreign body response (FBR) caused by biomaterials can essentially be understood as the interaction between the immune microenvironment and biomaterials, which has severely impeded the application of biomaterials in tissue repair. This concrete interaction occurs via cells and bioactive substanc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.820940/full |
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| author | Yi Chen Weiyan Sun Hai Tang Yingze Li Yingze Li Chen Li Long Wang Jiafei Chen Weikang Lin Shenghui Li Ziwen Fan Yu Cheng Yu Cheng Chang Chen |
| author_facet | Yi Chen Weiyan Sun Hai Tang Yingze Li Yingze Li Chen Li Long Wang Jiafei Chen Weikang Lin Shenghui Li Ziwen Fan Yu Cheng Yu Cheng Chang Chen |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | The foreign body response (FBR) caused by biomaterials can essentially be understood as the interaction between the immune microenvironment and biomaterials, which has severely impeded the application of biomaterials in tissue repair. This concrete interaction occurs via cells and bioactive substances, such as proteins and nucleic acids. These cellular and molecular interactions provide important cues for determining which element to incorporate into immunomodulatory biomaterials (IMBs), and IMBs can thus be endowed with the ability to modulate the FBR and repair damaged tissue. In terms of cellular, IMBs are modified to modulate functions of immune cells, such as macrophages and mast cells. In terms of bioactive substances, proteins and nucleic acids are delivered to influence the immune microenvironment. Meanwhile, IMBs are designed with high affinity for spatial targets and the ability to self-adapt over time, which allows for more efficient and intelligent tissue repair. Hence, IMB may achieve the perfect functional integration in the host, representing a breakthrough in tissue repair and regeneration medicine. |
| first_indexed | 2024-04-14T04:54:09Z |
| format | Article |
| id | doaj.art-b24cf3971e2e419fa5cbd9f5dc6fc352 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-14T04:54:09Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b24cf3971e2e419fa5cbd9f5dc6fc3522022-12-22T02:11:11ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.820940820940Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue RepairYi Chen0Weiyan Sun1Hai Tang2Yingze Li3Yingze Li4Chen Li5Long Wang6Jiafei Chen7Weikang Lin8Shenghui Li9Ziwen Fan10Yu Cheng11Yu Cheng12Chang Chen13Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaInstitute for Regenerative Medicine, Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaSchool of Materials Science and Engineering, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaInstitute for Regenerative Medicine, Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaThe Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaThe foreign body response (FBR) caused by biomaterials can essentially be understood as the interaction between the immune microenvironment and biomaterials, which has severely impeded the application of biomaterials in tissue repair. This concrete interaction occurs via cells and bioactive substances, such as proteins and nucleic acids. These cellular and molecular interactions provide important cues for determining which element to incorporate into immunomodulatory biomaterials (IMBs), and IMBs can thus be endowed with the ability to modulate the FBR and repair damaged tissue. In terms of cellular, IMBs are modified to modulate functions of immune cells, such as macrophages and mast cells. In terms of bioactive substances, proteins and nucleic acids are delivered to influence the immune microenvironment. Meanwhile, IMBs are designed with high affinity for spatial targets and the ability to self-adapt over time, which allows for more efficient and intelligent tissue repair. Hence, IMB may achieve the perfect functional integration in the host, representing a breakthrough in tissue repair and regeneration medicine.https://www.frontiersin.org/articles/10.3389/fbioe.2022.820940/fullimmunomodulatory biomaterialsforeign body responsetissue repairimmune microenvironmentself-adaptive interaction |
| spellingShingle | Yi Chen Weiyan Sun Hai Tang Yingze Li Yingze Li Chen Li Long Wang Jiafei Chen Weikang Lin Shenghui Li Ziwen Fan Yu Cheng Yu Cheng Chang Chen Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair Frontiers in Bioengineering and Biotechnology immunomodulatory biomaterials foreign body response tissue repair immune microenvironment self-adaptive interaction |
| title | Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair |
| title_full | Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair |
| title_fullStr | Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair |
| title_full_unstemmed | Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair |
| title_short | Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair |
| title_sort | interactions between immunomodulatory biomaterials and immune microenvironment cues for immunomodulation strategies in tissue repair |
| topic | immunomodulatory biomaterials foreign body response tissue repair immune microenvironment self-adaptive interaction |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.820940/full |
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