Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association
Abstract. Background:. Coronavirus disease 2019 (COVID-19) has an established impact on multiple organ systems, including the vascular and urogenital systems. Vascular effects may include venous thromboembolic disease, which could theoretically be a precursor to priapism—a urological emergency defin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2022-06-01
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| Series: | Current Urology |
| Online Access: | http://journals.lww.com/10.1097/CU9.0000000000000111 |
| _version_ | 1797976945537843200 |
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| author | Dominic Mpumelelo Malinga Abdullah E. Laher Jared McDowall Ahmed Adam |
| author_facet | Dominic Mpumelelo Malinga Abdullah E. Laher Jared McDowall Ahmed Adam |
| author_sort | Dominic Mpumelelo Malinga |
| collection | DOAJ |
| description | Abstract. Background:. Coronavirus disease 2019 (COVID-19) has an established impact on multiple organ systems, including the vascular and urogenital systems. Vascular effects may include venous thromboembolic disease, which could theoretically be a precursor to priapism—a urological emergency defined as an abnormal condition of prolonged penile erection lasting >4 hours. To better explore this association, we critically appraised all the published COVID-19 cases associated with priapism.
Materials and methods:. After PROSPERO registration (CRD42021245257), a systematic search of Google Scholar, Scopus, Embase, Web of Science, PubMed, Cumulative Index to Nursing and Allied Health Literature, Global Index Medicus, and Cochrane Database of Systematic Reviews was performed using specific search terms. The following study metadata were extracted: age, requirement for respiratory support, cavernous blood gas findings, management of priapism, and patient outcomes.
Results:. Fifteen single-patient case reports were included in this review. Of these, all of the patients presented with ischemic priapism, 9 patients (60.0%) were >60 years of age, 4 (26.7%) reported more than a single episode of priapism, 11 (73.3%) presented with pneumonia, 8 (53.3%) required mechanical ventilation, D-dimer was elevated in 5 of the 6 (83.3%) patients in whom this was reported, and among the 13 patients in whom mortality was reported, 4 (30.8%) died.
Conclusions:. Early reports suggest a prognostic relationship between COVID-19 and coexisting priapism. However, owing to commonalities in their pathophysiology and the small dataset reported in the literature, the probable association between COVID-19 and priapism is still theoretical. Further research is needed to confirm this association. |
| first_indexed | 2024-04-11T04:59:06Z |
| format | Article |
| id | doaj.art-b24d1390777f49a9bf7f34c2fed75451 |
| institution | Directory Open Access Journal |
| issn | 1661-7649 1661-7657 |
| language | English |
| last_indexed | 2024-04-11T04:59:06Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Current Urology |
| spelling | doaj.art-b24d1390777f49a9bf7f34c2fed754512022-12-26T06:01:49ZengWolters Kluwer HealthCurrent Urology1661-76491661-76572022-06-01162556210.1097/CU9.0000000000000111202206000-00001Coronavirus disease 2019 (COVID-19) and priapism: An unexplored associationDominic Mpumelelo MalingaAbdullah E. LaherJared McDowallAhmed AdamAbstract. Background:. Coronavirus disease 2019 (COVID-19) has an established impact on multiple organ systems, including the vascular and urogenital systems. Vascular effects may include venous thromboembolic disease, which could theoretically be a precursor to priapism—a urological emergency defined as an abnormal condition of prolonged penile erection lasting >4 hours. To better explore this association, we critically appraised all the published COVID-19 cases associated with priapism. Materials and methods:. After PROSPERO registration (CRD42021245257), a systematic search of Google Scholar, Scopus, Embase, Web of Science, PubMed, Cumulative Index to Nursing and Allied Health Literature, Global Index Medicus, and Cochrane Database of Systematic Reviews was performed using specific search terms. The following study metadata were extracted: age, requirement for respiratory support, cavernous blood gas findings, management of priapism, and patient outcomes. Results:. Fifteen single-patient case reports were included in this review. Of these, all of the patients presented with ischemic priapism, 9 patients (60.0%) were >60 years of age, 4 (26.7%) reported more than a single episode of priapism, 11 (73.3%) presented with pneumonia, 8 (53.3%) required mechanical ventilation, D-dimer was elevated in 5 of the 6 (83.3%) patients in whom this was reported, and among the 13 patients in whom mortality was reported, 4 (30.8%) died. Conclusions:. Early reports suggest a prognostic relationship between COVID-19 and coexisting priapism. However, owing to commonalities in their pathophysiology and the small dataset reported in the literature, the probable association between COVID-19 and priapism is still theoretical. Further research is needed to confirm this association.http://journals.lww.com/10.1097/CU9.0000000000000111 |
| spellingShingle | Dominic Mpumelelo Malinga Abdullah E. Laher Jared McDowall Ahmed Adam Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association Current Urology |
| title | Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association |
| title_full | Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association |
| title_fullStr | Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association |
| title_full_unstemmed | Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association |
| title_short | Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association |
| title_sort | coronavirus disease 2019 covid 19 and priapism an unexplored association |
| url | http://journals.lww.com/10.1097/CU9.0000000000000111 |
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