Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches

Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches

Sodium-glucose co-transporter type 2 (SGLT 2, gliflozins) inhibitors are potent orally active drugs approved for managing type 2 diabetes. SGLT 2 inhibitors exert a glucose-lowering effect by suppressing sodium-glucose co-transporters 1 and 2 in the intestinal and kidney proximal tubules. In this st...

Full description

Bibliographic Details
Main Authors: Yu Zhang, Panpan Xie, Yamei Li, Zhixing Chen, Aixin Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
type 2 diabetes mellitus (T2DM)
SGLT2 inhibitors
physiologically-based pharmacokinetic model
inhibitory effect
sodium-glucose cotransporter 1 and 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1142003/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1142003/full

Similar Items