Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii
Carbapenemase-producing <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) is resistant to most of the available antibiotics and poses serious therapeutic challenges. The study investigated <i>Monsonia angustifolia</i> (<i>M. angustifolia</i>) and &l...
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MDPI AG
2022-09-01
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author | Noel-David Nogbou Dimpho Raesibe Mabela Buang Matseke Ntwanano Sipho Mapfumari Mmammosheledi Elsie Mothibe Lawrence Chikwelu Obi Andrew Munyalo Musyoki |
author_facet | Noel-David Nogbou Dimpho Raesibe Mabela Buang Matseke Ntwanano Sipho Mapfumari Mmammosheledi Elsie Mothibe Lawrence Chikwelu Obi Andrew Munyalo Musyoki |
author_sort | Noel-David Nogbou |
collection | DOAJ |
description | Carbapenemase-producing <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) is resistant to most of the available antibiotics and poses serious therapeutic challenges. The study investigated <i>Monsonia angustifolia</i> (<i>M. angustifolia</i>) and <i>Momordica balsamina Linn</i> (<i>M. balsamina Linn</i>) extracts for antibacterial activity against a clinical isolate of carbapenemase-producing <i>A. baumannii</i> using the Kirby Bauer disc diffusion and TLC coupled with bioautography. MIC determination experiments were conducted on a molecularly characterized <i>A. baumannii</i> isolate identified using VITEK2. Positive PCR detection of <i>bla<sub>OXA-51</sub></i> and <i>bla<sub>OXA-23</sub></i> confirmed isolate identity and the presence of a carbapenemase-encoding gene. Antibacterial activity was observed with the methanolic extract of <i>M. balsamina Linn</i> with a MIC of 0.5 mg/mL. Compounds with Rf values of 0.05; 0.17; 0.39 obtained from <i>M. angustifolia</i> hexane extract; compounds with Rf values of 0.58; 0.78; 0.36; 0.48; 0.5; 0.56; 0.67; 0.9 obtained from <i>M. angustifolia</i> dichloromethane extract; compounds with Rf values of 0.11; 0.56; 0.24; 0.37 obtained from <i>M. angustifolia</i> acetone extract and compounds with Rf values of 0.11; 0.27 obtained from <i>M. angustifolia</i> methanol extract demonstrated a level of antibacterial activity. <i>M. angustifolia</i> and <i>M. balsamina Linn</i> plant extracts have a clinically significant antibacterial activity against a carbapenemase-producing <i>A. baumannii</i> strain. |
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spelling | doaj.art-b24e7fb9f9a543859fd808a7f7b0937c2023-11-23T18:26:50ZengMDPI AGPlants2223-77472022-09-011118237410.3390/plants11182374Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter BaumanniiNoel-David Nogbou0Dimpho Raesibe Mabela1Buang Matseke2Ntwanano Sipho Mapfumari3Mmammosheledi Elsie Mothibe4Lawrence Chikwelu Obi5Andrew Munyalo Musyoki6Department of Microbiological Pathology, School of Medicine, Sefako Makgatho Health Sciences University, P.O. Box 211, Pretoria 0208, South AfricaDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South AfricaDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South AfricaDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South AfricaDepartment of Pharmacology, School of Pharmacy, Rhodes University, P.O. Box 94, Grahamstown 6139, South AfricaFaculty of Science and Technology, Sefako Makgatho Health Sciences University, P.O Box 138, Pretoria 0204, South AfricaDepartment of Microbiological Pathology, School of Medicine, Sefako Makgatho Health Sciences University, P.O. Box 211, Pretoria 0208, South AfricaCarbapenemase-producing <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) is resistant to most of the available antibiotics and poses serious therapeutic challenges. The study investigated <i>Monsonia angustifolia</i> (<i>M. angustifolia</i>) and <i>Momordica balsamina Linn</i> (<i>M. balsamina Linn</i>) extracts for antibacterial activity against a clinical isolate of carbapenemase-producing <i>A. baumannii</i> using the Kirby Bauer disc diffusion and TLC coupled with bioautography. MIC determination experiments were conducted on a molecularly characterized <i>A. baumannii</i> isolate identified using VITEK2. Positive PCR detection of <i>bla<sub>OXA-51</sub></i> and <i>bla<sub>OXA-23</sub></i> confirmed isolate identity and the presence of a carbapenemase-encoding gene. Antibacterial activity was observed with the methanolic extract of <i>M. balsamina Linn</i> with a MIC of 0.5 mg/mL. Compounds with Rf values of 0.05; 0.17; 0.39 obtained from <i>M. angustifolia</i> hexane extract; compounds with Rf values of 0.58; 0.78; 0.36; 0.48; 0.5; 0.56; 0.67; 0.9 obtained from <i>M. angustifolia</i> dichloromethane extract; compounds with Rf values of 0.11; 0.56; 0.24; 0.37 obtained from <i>M. angustifolia</i> acetone extract and compounds with Rf values of 0.11; 0.27 obtained from <i>M. angustifolia</i> methanol extract demonstrated a level of antibacterial activity. <i>M. angustifolia</i> and <i>M. balsamina Linn</i> plant extracts have a clinically significant antibacterial activity against a carbapenemase-producing <i>A. baumannii</i> strain.https://www.mdpi.com/2223-7747/11/18/2374antibacterial activityplant extract<i>M. balsamina Linn</i><i>M. angustifolia</i>carbapenemase-producing <i>A. baumannii</i> |
spellingShingle | Noel-David Nogbou Dimpho Raesibe Mabela Buang Matseke Ntwanano Sipho Mapfumari Mmammosheledi Elsie Mothibe Lawrence Chikwelu Obi Andrew Munyalo Musyoki Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii Plants antibacterial activity plant extract <i>M. balsamina Linn</i> <i>M. angustifolia</i> carbapenemase-producing <i>A. baumannii</i> |
title | Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii |
title_full | Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii |
title_fullStr | Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii |
title_full_unstemmed | Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii |
title_short | Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii |
title_sort | antibacterial activities of monsonia angustifolia and momordica balsamina linn extracts against carbapenem resistant acinetobacter baumannii |
topic | antibacterial activity plant extract <i>M. balsamina Linn</i> <i>M. angustifolia</i> carbapenemase-producing <i>A. baumannii</i> |
url | https://www.mdpi.com/2223-7747/11/18/2374 |
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