Endocannabinoid modulation of dopaminergic motor circuits
There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In fact, the administration of plant-derived, synt...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-06-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00110/full |
| _version_ | 1828484149494677504 |
|---|---|
| author | Teresa eMorera-Herreras Teresa eMorera-Herreras Cristina eMiguelez Asier eAristieta José Ángel eRuiz-Ortega José Ángel eRuiz-Ortega Luisa eUgedo |
| author_facet | Teresa eMorera-Herreras Teresa eMorera-Herreras Cristina eMiguelez Asier eAristieta José Ángel eRuiz-Ortega José Ángel eRuiz-Ortega Luisa eUgedo |
| author_sort | Teresa eMorera-Herreras |
| collection | DOAJ |
| description | There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In fact, the administration of plant-derived, synthetic or endogenous cannabinoids produces several effects on motor function. These effects are mediated primarily through the CB1 receptors that are densely located in the dopamine-enriched basal ganglia networks, suggesting that the motor effects of endocannabinoids are due, at least in part, to modulation of dopaminergic transmission.On the other hand, there are profound changes in CB1 receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in Parkinson´s disease) and following L-DOPA replacement therapy. Therefore, it has been suggested that endocannabinoid system modulation may constitute an important component in new therapeutic approaches to the treatment of motor disturbances. In this article we will review studies supporting the endocannabinoid modulation of dopaminergic motor circuits. |
| first_indexed | 2024-12-11T08:50:50Z |
| format | Article |
| id | doaj.art-b24e8c12015b4041917044df413ebb04 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T08:50:50Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b24e8c12015b4041917044df413ebb042022-12-22T01:14:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-06-01310.3389/fphar.2012.0011027203Endocannabinoid modulation of dopaminergic motor circuitsTeresa eMorera-Herreras0Teresa eMorera-Herreras1Cristina eMiguelez2Asier eAristieta3José Ángel eRuiz-Ortega4José Ángel eRuiz-Ortega5Luisa eUgedo6Faculty of Medicine and Dentistry. University of the Basque CountryFaculty of Pharmacy. University of the Basque CountryFaculty of Medicine and Dentistry. University of the Basque CountryFaculty of Medicine and Dentistry. University of the Basque CountryFaculty of Medicine and Dentistry. University of the Basque CountryFaculty of Pharmacy. University of the Basque CountryFaculty of Medicine and Dentistry. University of the Basque CountryThere is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In fact, the administration of plant-derived, synthetic or endogenous cannabinoids produces several effects on motor function. These effects are mediated primarily through the CB1 receptors that are densely located in the dopamine-enriched basal ganglia networks, suggesting that the motor effects of endocannabinoids are due, at least in part, to modulation of dopaminergic transmission.On the other hand, there are profound changes in CB1 receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in Parkinson´s disease) and following L-DOPA replacement therapy. Therefore, it has been suggested that endocannabinoid system modulation may constitute an important component in new therapeutic approaches to the treatment of motor disturbances. In this article we will review studies supporting the endocannabinoid modulation of dopaminergic motor circuits.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00110/fullBasal GangliaDopamineElectrophysiologyEndocannabinoidsMotor circuits |
| spellingShingle | Teresa eMorera-Herreras Teresa eMorera-Herreras Cristina eMiguelez Asier eAristieta José Ángel eRuiz-Ortega José Ángel eRuiz-Ortega Luisa eUgedo Endocannabinoid modulation of dopaminergic motor circuits Frontiers in Pharmacology Basal Ganglia Dopamine Electrophysiology Endocannabinoids Motor circuits |
| title | Endocannabinoid modulation of dopaminergic motor circuits |
| title_full | Endocannabinoid modulation of dopaminergic motor circuits |
| title_fullStr | Endocannabinoid modulation of dopaminergic motor circuits |
| title_full_unstemmed | Endocannabinoid modulation of dopaminergic motor circuits |
| title_short | Endocannabinoid modulation of dopaminergic motor circuits |
| title_sort | endocannabinoid modulation of dopaminergic motor circuits |
| topic | Basal Ganglia Dopamine Electrophysiology Endocannabinoids Motor circuits |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00110/full |
| work_keys_str_mv | AT teresaemoreraherreras endocannabinoidmodulationofdopaminergicmotorcircuits AT teresaemoreraherreras endocannabinoidmodulationofdopaminergicmotorcircuits AT cristinaemiguelez endocannabinoidmodulationofdopaminergicmotorcircuits AT asierearistieta endocannabinoidmodulationofdopaminergicmotorcircuits AT joseangeleruizortega endocannabinoidmodulationofdopaminergicmotorcircuits AT joseangeleruizortega endocannabinoidmodulationofdopaminergicmotorcircuits AT luisaeugedo endocannabinoidmodulationofdopaminergicmotorcircuits |