Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study
ObjectivesSeveral studies have reported risk factors for severe disease and mortality in hospitalized adults with RSV infections. There is limited information available regarding the factors that affect the duration of a patient’s hospital length of stay (LOS).MethodsThis was a multicenter historica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1385439/full |
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| author | Ambreen Malik Susan Szpunar Mamta Sharma Leonard B. Johnson Leonard B. Johnson Louis Saravolatz Louis Saravolatz Ashish Bhargava Ashish Bhargava |
| author_facet | Ambreen Malik Susan Szpunar Mamta Sharma Leonard B. Johnson Leonard B. Johnson Louis Saravolatz Louis Saravolatz Ashish Bhargava Ashish Bhargava |
| author_sort | Ambreen Malik |
| collection | DOAJ |
| description | ObjectivesSeveral studies have reported risk factors for severe disease and mortality in hospitalized adults with RSV infections. There is limited information available regarding the factors that affect the duration of a patient’s hospital length of stay (LOS).MethodsThis was a multicenter historical cohort study of adult patients hospitalized for laboratory-confirmed RSV in Southeast Michigan between January 2017 and December 2021. Hospitalized patients were identified using the International Classification of Diseases, Tenth Revision 10 codes for RSV infection. Mean LOS was computed; prolonged LOS was defined as greater than the mean.ResultsWe included 360 patients with a mean age (SD) of 69.9 ± 14.7 years, 63.6% (229) were female and 63.3% (228) of white race. The mean hospital LOS was 7.1 ± 5.4 days. Factors associated with prolonged LOS in univariable analysis were old age, body mass index (BMI), smoking status, Charlson Weighted Index of Comorbidity (CWIC), home oxygen, abnormal chest x-ray (CXR), presence of sepsis, use of oxygen, and antibiotics at the time of presentation. Predictors for prolonged LOS on admission in multivariable analysis were age on admission (p < 0.001), smoking status (p = 0.001), CWIC (p = 0.038) and abnormal CXR (p = 0.043).InterpretationOur study found that age on admission, smoking history, higher CWIC and abnormal CXR on admission were significantly associated with prolonged LOS among adult patients hospitalized with RSV infection. These findings highlight the significance of promptly recognizing and implementing early interventions to mitigate the duration of hospitalization for adult patients suffering from RSV infection. |
| first_indexed | 2024-04-24T13:47:26Z |
| format | Article |
| id | doaj.art-b2513e57c93a4232a12dc9bd6a9d8727 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T13:47:26Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b2513e57c93a4232a12dc9bd6a9d87272024-04-04T05:08:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-04-011510.3389/fmicb.2024.13854391385439Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort studyAmbreen Malik0Susan Szpunar1Mamta Sharma2Leonard B. Johnson3Leonard B. Johnson4Louis Saravolatz5Louis Saravolatz6Ashish Bhargava7Ashish Bhargava8Division of Infectious Diseases, Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, United StatesDepartment of Biomedical Investigations and Research, Ascension St. John Hospital, Detroit, MI, United StatesDivision of Infectious Diseases, Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, United StatesDivision of Infectious Diseases, Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, United StatesThomas Mackey Center for Infectious Disease Research, Ascension St. John Hospital, Detroit, MI, United StatesDivision of Infectious Diseases, Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, United StatesThomas Mackey Center for Infectious Disease Research, Ascension St. John Hospital, Detroit, MI, United StatesDivision of Infectious Diseases, Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, United StatesThomas Mackey Center for Infectious Disease Research, Ascension St. John Hospital, Detroit, MI, United StatesObjectivesSeveral studies have reported risk factors for severe disease and mortality in hospitalized adults with RSV infections. There is limited information available regarding the factors that affect the duration of a patient’s hospital length of stay (LOS).MethodsThis was a multicenter historical cohort study of adult patients hospitalized for laboratory-confirmed RSV in Southeast Michigan between January 2017 and December 2021. Hospitalized patients were identified using the International Classification of Diseases, Tenth Revision 10 codes for RSV infection. Mean LOS was computed; prolonged LOS was defined as greater than the mean.ResultsWe included 360 patients with a mean age (SD) of 69.9 ± 14.7 years, 63.6% (229) were female and 63.3% (228) of white race. The mean hospital LOS was 7.1 ± 5.4 days. Factors associated with prolonged LOS in univariable analysis were old age, body mass index (BMI), smoking status, Charlson Weighted Index of Comorbidity (CWIC), home oxygen, abnormal chest x-ray (CXR), presence of sepsis, use of oxygen, and antibiotics at the time of presentation. Predictors for prolonged LOS on admission in multivariable analysis were age on admission (p < 0.001), smoking status (p = 0.001), CWIC (p = 0.038) and abnormal CXR (p = 0.043).InterpretationOur study found that age on admission, smoking history, higher CWIC and abnormal CXR on admission were significantly associated with prolonged LOS among adult patients hospitalized with RSV infection. These findings highlight the significance of promptly recognizing and implementing early interventions to mitigate the duration of hospitalization for adult patients suffering from RSV infection.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1385439/fullrespiratory syncytial virus (RSV)predictorsrisk factorshospital length of stayprolonged hospital length of stay |
| spellingShingle | Ambreen Malik Susan Szpunar Mamta Sharma Leonard B. Johnson Leonard B. Johnson Louis Saravolatz Louis Saravolatz Ashish Bhargava Ashish Bhargava Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study Frontiers in Microbiology respiratory syncytial virus (RSV) predictors risk factors hospital length of stay prolonged hospital length of stay |
| title | Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study |
| title_full | Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study |
| title_fullStr | Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study |
| title_full_unstemmed | Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study |
| title_short | Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections – a multi-center historical cohort study |
| title_sort | predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections a multi center historical cohort study |
| topic | respiratory syncytial virus (RSV) predictors risk factors hospital length of stay prolonged hospital length of stay |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1385439/full |
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