Ultrasound Thermometry for HIFU-Therapy
High-Intensity Focused Ultrasound (HIFU) is an alternative tumour therapy with the ability for non-invasive thermal ablation of tissue. For a safe application, the heat deposition needs to be monitored over time, which is currently done with Magnetic Resonance Imaging. Ultrasound (US) based monitori...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-10-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2021-2141 |
| _version_ | 1811194237531717632 |
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| author | Daschner Rosa Hewener Holger Bost Wolfgang Weber Steffen Tretbar Steffen Fournelle Marc |
| author_facet | Daschner Rosa Hewener Holger Bost Wolfgang Weber Steffen Tretbar Steffen Fournelle Marc |
| author_sort | Daschner Rosa |
| collection | DOAJ |
| description | High-Intensity Focused Ultrasound (HIFU) is an alternative tumour therapy with the ability for non-invasive thermal ablation of tissue. For a safe application, the heat deposition needs to be monitored over time, which is currently done with Magnetic Resonance Imaging. Ultrasound (US) based monitoring is a promising alternative, as it is less expensive and allows the use of a single device for both therapy and monitoring. In this work, a method for spatial and temporal US thermometry has been investigated based on simulation studies and in-vitro measurements. The chosen approach is based on the approximately linear dependence between temperature and speed of sound (SoS) in tissue for a given temperature range. By tracking the speckles of successive B-images, the possibility of detecting local changes in SoS and therefore in temperature is given. A speckle tracking algorithm was implemented for 2D and 3D US thermometry using a spatial compounding method to reduce artifacts. The algorithm was experimentally validated in an agar-based phantom and in porcine tissue for temperature rises up to △ 8°C. We used a focusing single element US transducer as therapeutic probe, a linear (/matrix array) transducer with 128 (/32∙32) elements for imaging and thermocouples for validation and calibration. In all experiments, both computational and in-vitro, we succeeded in monitoring the thermal induced SoS changes over time. The in-vitro measurements were in good agreement with the simulation results and the thermocouple measurements (rms temperature difference = 0.53 °C, rms correlation coefficient = 0. 96). |
| first_indexed | 2024-04-12T00:22:33Z |
| format | Article |
| id | doaj.art-b251656e70794049adc1afd0fdaa1aa9 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-12T00:22:33Z |
| publishDate | 2021-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-b251656e70794049adc1afd0fdaa1aa92022-12-22T03:55:41ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042021-10-017255455710.1515/cdbme-2021-2141Ultrasound Thermometry for HIFU-TherapyDaschner Rosa0Hewener Holger1Bost Wolfgang2Weber Steffen3Tretbar Steffen4Fournelle Marc5Fraunhofer Institute for Biomedical Engineering,Sulzbach/Saar, GermanyFraunhofer Institute for Biomedical Engineering,Sulzbach/Saar, GermanyFraunhofer Institute for Biomedical Engineering,Sulzbach/Saar, GermanyFraunhofer Institute for Biomedical Engineering,Sulzbach/Saar, GermanyFraunhofer Institute for Biomedical Engineering,Sulzbach/Saar, GermanyFraunhofer Institute for Biomedical Engineering (IBMT), Joseph-von-Fraunhofer-Weg 1, 66280Sulzbach/Saar, GermanyHigh-Intensity Focused Ultrasound (HIFU) is an alternative tumour therapy with the ability for non-invasive thermal ablation of tissue. For a safe application, the heat deposition needs to be monitored over time, which is currently done with Magnetic Resonance Imaging. Ultrasound (US) based monitoring is a promising alternative, as it is less expensive and allows the use of a single device for both therapy and monitoring. In this work, a method for spatial and temporal US thermometry has been investigated based on simulation studies and in-vitro measurements. The chosen approach is based on the approximately linear dependence between temperature and speed of sound (SoS) in tissue for a given temperature range. By tracking the speckles of successive B-images, the possibility of detecting local changes in SoS and therefore in temperature is given. A speckle tracking algorithm was implemented for 2D and 3D US thermometry using a spatial compounding method to reduce artifacts. The algorithm was experimentally validated in an agar-based phantom and in porcine tissue for temperature rises up to △ 8°C. We used a focusing single element US transducer as therapeutic probe, a linear (/matrix array) transducer with 128 (/32∙32) elements for imaging and thermocouples for validation and calibration. In all experiments, both computational and in-vitro, we succeeded in monitoring the thermal induced SoS changes over time. The in-vitro measurements were in good agreement with the simulation results and the thermocouple measurements (rms temperature difference = 0.53 °C, rms correlation coefficient = 0. 96).https://doi.org/10.1515/cdbme-2021-2141ultrasound thermometrythermal strainthermoacoustic lens effectplane wave compounding |
| spellingShingle | Daschner Rosa Hewener Holger Bost Wolfgang Weber Steffen Tretbar Steffen Fournelle Marc Ultrasound Thermometry for HIFU-Therapy Current Directions in Biomedical Engineering ultrasound thermometry thermal strain thermoacoustic lens effect plane wave compounding |
| title | Ultrasound Thermometry for HIFU-Therapy |
| title_full | Ultrasound Thermometry for HIFU-Therapy |
| title_fullStr | Ultrasound Thermometry for HIFU-Therapy |
| title_full_unstemmed | Ultrasound Thermometry for HIFU-Therapy |
| title_short | Ultrasound Thermometry for HIFU-Therapy |
| title_sort | ultrasound thermometry for hifu therapy |
| topic | ultrasound thermometry thermal strain thermoacoustic lens effect plane wave compounding |
| url | https://doi.org/10.1515/cdbme-2021-2141 |
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