DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke
PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1132393/full |
| _version_ | 1797855284063895552 |
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| author | Yue Qin Yue Qin Xin Li Yanqiang Qiao Yanqiang Qiao Huili Zou Yifan Qian Xiaoshi Li Yinhu Zhu Wenli Huo Lei Wang Lei Wang Ming Zhang |
| author_facet | Yue Qin Yue Qin Xin Li Yanqiang Qiao Yanqiang Qiao Huili Zou Yifan Qian Xiaoshi Li Yinhu Zhu Wenli Huo Lei Wang Lei Wang Ming Zhang |
| author_sort | Yue Qin |
| collection | DOAJ |
| description | PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.MethodsTwenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.ResultsSix IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group (t = −3.02, p = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, p = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA (R = −0.55, p = 0.023) and MD (R = −0.48, p = 0.032) values of the right CST were found.ConclusionsGlymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS. |
| first_indexed | 2024-04-09T20:20:05Z |
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| id | doaj.art-b252e82a913e4c1ea71926d07ebfa70c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T20:20:05Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-b252e82a913e4c1ea71926d07ebfa70c2023-03-31T05:55:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11323931132393DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic strokeYue Qin0Yue Qin1Xin Li2Yanqiang Qiao3Yanqiang Qiao4Huili Zou5Yifan Qian6Xiaoshi Li7Yinhu Zhu8Wenli Huo9Lei Wang10Lei Wang11Ming Zhang12Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Rehabilitation Medicine, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Radiology, Xi'an Daxing Hospital, Xi'an, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaPurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.MethodsTwenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.ResultsSix IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group (t = −3.02, p = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, p = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA (R = −0.55, p = 0.023) and MD (R = −0.48, p = 0.032) values of the right CST were found.ConclusionsGlymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.https://www.frontiersin.org/articles/10.3389/fnins.2023.1132393/fullglymphatic systemischemic strokeanalysis along perivascular spacecorticospinal tractmotor dysfunction |
| spellingShingle | Yue Qin Yue Qin Xin Li Yanqiang Qiao Yanqiang Qiao Huili Zou Yifan Qian Xiaoshi Li Yinhu Zhu Wenli Huo Lei Wang Lei Wang Ming Zhang DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke Frontiers in Neuroscience glymphatic system ischemic stroke analysis along perivascular space corticospinal tract motor dysfunction |
| title | DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke |
| title_full | DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke |
| title_fullStr | DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke |
| title_full_unstemmed | DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke |
| title_short | DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke |
| title_sort | dti alps an mr biomarker for motor dysfunction in patients with subacute ischemic stroke |
| topic | glymphatic system ischemic stroke analysis along perivascular space corticospinal tract motor dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1132393/full |
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