Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/6/3/113 |
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| author | Aleksandra Ignjatović Valentina Arsić-Arsenijević Milan Golubović Saša Đenić Stefan Momčilović Aleksandra Trajković Marina Ranđelović Vojislav Ćirić Suzana Otašević |
| author_facet | Aleksandra Ignjatović Valentina Arsić-Arsenijević Milan Golubović Saša Đenić Stefan Momčilović Aleksandra Trajković Marina Ranđelović Vojislav Ćirić Suzana Otašević |
| author_sort | Aleksandra Ignjatović |
| collection | DOAJ |
| description | Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS). The goals are to evaluate the distribution of species causing RVVC, their in-vitro susceptibility to antifungals, and the patient’s QoL. Additionally, the clinical characteristics are analyzed using cluster analysis. Prospective analysis of data was performed for women diagnosed with RVVC in the period from January 2016 to December 2019 based on the analysis of data from a single-center’s records. The standard mycological methods and antifungal susceptibility testing were done. Clinical characteristics and QoL were examined by appropriate questions. The cluster analysis was used to identify clusters of SS. A total of 320 women were diagnosed. The dominant species was <i>Candida (C.) albicans</i>. Non-<i>albicans Candida</i> (NAC) yeast was found in 24.4%, and the most common was <i>C. glabrata</i>. Interestingly, <i>Saccharomyces (S.) cerevisiae</i> was detected in 2%. All of the isolated species, except <i>C. parapsilosis</i> and <i>C. kefyr,</i> demonstrated reduced susceptibility to antifungals. We confirmed the emergence of the NAC species and <i>S. cerevisiae</i> with reduced susceptibility to antifungals. Cluster analysis represented by a dendrogram revealed three SS clusters: irritation, uncommon, and discharge, but further studies are needed to examine the relationship between clusters, <i>Candida</i> strains, and outcomes. |
| first_indexed | 2024-03-10T18:19:09Z |
| format | Article |
| id | doaj.art-b254485408114878b0df1574230f0247 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T18:19:09Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b254485408114878b0df1574230f02472023-11-20T07:30:18ZengMDPI AGJournal of Fungi2309-608X2020-07-016311310.3390/jof6030113Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based InvestigationAleksandra Ignjatović0Valentina Arsić-Arsenijević1Milan Golubović2Saša Đenić3Stefan Momčilović4Aleksandra Trajković5Marina Ranđelović6Vojislav Ćirić7Suzana Otašević8Department of Medical Statistics and Informatics, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaDepartment of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaFaculty of Medicine, University of Niš, 18000 Niš, SerbiaFaculty of Medicine, University of Niš, 18000 Niš, SerbiaFaculty of Medicine, University of Niš, 18000 Niš, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaPublic Health Institute Niš, 18000 Niš, SerbiaDepartment of Internal Medicine, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaPublic Health Institute Niš, 18000 Niš, SerbiaRecurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS). The goals are to evaluate the distribution of species causing RVVC, their in-vitro susceptibility to antifungals, and the patient’s QoL. Additionally, the clinical characteristics are analyzed using cluster analysis. Prospective analysis of data was performed for women diagnosed with RVVC in the period from January 2016 to December 2019 based on the analysis of data from a single-center’s records. The standard mycological methods and antifungal susceptibility testing were done. Clinical characteristics and QoL were examined by appropriate questions. The cluster analysis was used to identify clusters of SS. A total of 320 women were diagnosed. The dominant species was <i>Candida (C.) albicans</i>. Non-<i>albicans Candida</i> (NAC) yeast was found in 24.4%, and the most common was <i>C. glabrata</i>. Interestingly, <i>Saccharomyces (S.) cerevisiae</i> was detected in 2%. All of the isolated species, except <i>C. parapsilosis</i> and <i>C. kefyr,</i> demonstrated reduced susceptibility to antifungals. We confirmed the emergence of the NAC species and <i>S. cerevisiae</i> with reduced susceptibility to antifungals. Cluster analysis represented by a dendrogram revealed three SS clusters: irritation, uncommon, and discharge, but further studies are needed to examine the relationship between clusters, <i>Candida</i> strains, and outcomes.https://www.mdpi.com/2309-608X/6/3/113<i>Candida</i>recurrent vulvovaginal candidiasisquality of lifesigns and symptomscluster analysis |
| spellingShingle | Aleksandra Ignjatović Valentina Arsić-Arsenijević Milan Golubović Saša Đenić Stefan Momčilović Aleksandra Trajković Marina Ranđelović Vojislav Ćirić Suzana Otašević Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation Journal of Fungi <i>Candida</i> recurrent vulvovaginal candidiasis quality of life signs and symptoms cluster analysis |
| title | Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation |
| title_full | Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation |
| title_fullStr | Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation |
| title_full_unstemmed | Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation |
| title_short | Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation |
| title_sort | recurrent vulvovaginal candidosis and cluster analysis of clinical signs and symptoms a laboratory based investigation |
| topic | <i>Candida</i> recurrent vulvovaginal candidiasis quality of life signs and symptoms cluster analysis |
| url | https://www.mdpi.com/2309-608X/6/3/113 |
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