KCNJ15 deficiency promotes drug resistance via affecting the function of lysosomes

KCNJ15 deficiency promotes drug resistance via affecting the function of lysosomes

The altered lysosomal function can induce drug redistribution which leads to drug resistance and poor prognosis for cancer patients. V-ATPase, an ATP-driven proton pump positioned at lysosomal surfaces, is responsible for maintaining the stability of lysosome. Herein, we reported that the potassium...

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Bibliographic Details
Main Authors: Xinbo Qiao, Yixiao Zhang, Zhan Zhang, Nan Niu, Haonan Li, Lisha Sun, Qingtian Ma, Jiawen Bu, Jinchi Liu, Guanglei Chen, Jinqi Xue, Yongliang Yang, Caigang Liu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Breast cancer
Cancer progression
Drug resistance
Lysosome
KCNJ15
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087623000417

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