A Commonly Used Biocide 2-N-octyl-4-isothiazolin-3-oneInduces Blood–Brain Barrier Dysfunction via Cellular Thiol Modification and Mitochondrial Damage

A Commonly Used Biocide 2-N-octyl-4-isothiazolin-3-oneInduces Blood–Brain Barrier Dysfunction via Cellular Thiol Modification and Mitochondrial Damage

Isothiazolinone (IT) biocides are potent antibacterial substances commonly used as preservatives or disinfectants, and 2-n-Octyl-4-isothiazolin-3-one (OIT; octhilinone) is a common IT biocide that is present in leather products, glue, paints, and cleaning products. Although humans are exposed to OIT...

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Bibliographic Details
Main Authors: Donghyun Kim, Eun-Hye Kim, Sungbin Choi, Kyung-Min Lim, Lu Tie, Arshad Majid, Ok-Nam Bae
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
isothiazolinone (IT) biocide
2-n-Octyl-4-isothiazolin-3-one (OIT)
blood–brain barrier (BBB) model
protein S-nitrosylation (SNO)
mitochondrial dysfunction
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/22/5/2563

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