Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity
Abstract Introduction It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity. Methods Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who h...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12160 |
| _version_ | 1817975389525377024 |
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| author | Mark A. Espeland Hussein Yassine Kathleen D. Hayden Christina Hugenschmidt Wendy L. Bennett Ariana Chao Rebecca Neiberg Steven E. Kahn José A. Luchsinger for the Action for Health in Diabetes (Look AHEAD) Research Group |
| author_facet | Mark A. Espeland Hussein Yassine Kathleen D. Hayden Christina Hugenschmidt Wendy L. Bennett Ariana Chao Rebecca Neiberg Steven E. Kahn José A. Luchsinger for the Action for Health in Diabetes (Look AHEAD) Research Group |
| author_sort | Mark A. Espeland |
| collection | DOAJ |
| description | Abstract Introduction It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity. Methods Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who had been enrolled in a clinical trial of weight loss intervention. Sex‐related differences in means and rates of decline of cognitive scores were assessed. Results Women outperformed men in verbal learning and processing speed (P < 0.001), but not executive function (P = 0.22). The rates of decline over time for women and men were similar (P ≥ 0.10); however women, but not men, with apolipoprotein E (APOE) ε4 alleles had steeper declines in verbal learning (P = 0.02) and processing speed (P = 0.007) than those without these alleles. Discussion Cognitive advantages for women with T2D and overweight/obesity over men are preserved as they age; however, these are eroded by the APOE ε4 genotype. |
| first_indexed | 2024-04-13T21:48:19Z |
| format | Article |
| id | doaj.art-b258b4a1837540cbaddffd063a078651 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-13T21:48:19Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-b258b4a1837540cbaddffd063a0786512022-12-22T02:28:29ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12160Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesityMark A. Espeland0Hussein Yassine1Kathleen D. Hayden2Christina Hugenschmidt3Wendy L. Bennett4Ariana Chao5Rebecca Neiberg6Steven E. Kahn7José A. Luchsinger8for the Action for Health in Diabetes (Look AHEAD) Research GroupDivision of Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston‐Salem North Carolina USADepartment of Medicine Keck School of Medicine University of Southern California, Los Angeles California USADepartment of Social Sciences and Health Policy Wake Forest School of Medicine Winston‐Salem North Carolina USADivision of Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston‐Salem North Carolina USADepartment of Internal Medicine The Johns Hopkins School of Medicine Baltimore Maryland USASchool of Nursing University of Pennsylvania Philadelphia Pennsylvania USADepartment of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem North Carolina USADivision of Metabolism, Endocrinology, and Nutrition VA Puget Sound Health Care System and University of Washington Seattle Washington USADepartments of Medicine and Epidemiology Columbia University Irving Medical Center New York New York USAAbstract Introduction It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity. Methods Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who had been enrolled in a clinical trial of weight loss intervention. Sex‐related differences in means and rates of decline of cognitive scores were assessed. Results Women outperformed men in verbal learning and processing speed (P < 0.001), but not executive function (P = 0.22). The rates of decline over time for women and men were similar (P ≥ 0.10); however women, but not men, with apolipoprotein E (APOE) ε4 alleles had steeper declines in verbal learning (P = 0.02) and processing speed (P = 0.007) than those without these alleles. Discussion Cognitive advantages for women with T2D and overweight/obesity over men are preserved as they age; however, these are eroded by the APOE ε4 genotype.https://doi.org/10.1002/trc2.12160apoliprotein E ε4cognitive declineobesitysextype 2 diabetes mellitus |
| spellingShingle | Mark A. Espeland Hussein Yassine Kathleen D. Hayden Christina Hugenschmidt Wendy L. Bennett Ariana Chao Rebecca Neiberg Steven E. Kahn José A. Luchsinger for the Action for Health in Diabetes (Look AHEAD) Research Group Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity Alzheimer’s & Dementia: Translational Research & Clinical Interventions apoliprotein E ε4 cognitive decline obesity sex type 2 diabetes mellitus |
| title | Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| title_full | Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| title_fullStr | Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| title_full_unstemmed | Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| title_short | Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| title_sort | sex related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity |
| topic | apoliprotein E ε4 cognitive decline obesity sex type 2 diabetes mellitus |
| url | https://doi.org/10.1002/trc2.12160 |
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