Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran
"nAbstract "n  "nIntroduction: Polymorphism in genes involved in folate metabolism may cotribute to the susceptibility to acute lymphoblastic leukemia (ALL). "nPatients and Methods: To examine the influence of polymorphism in thymidylate synthase (TS...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2010-01-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17132.pdf&manuscript_id=17132 |
| _version_ | 1797722788415406080 |
|---|---|
| author | Zohreh Rahimi Zainab Ahmadian Reza Akramipour Hamid Madani Hadi Mozafari Asad Vaisi-Raygani Ali Shahriari-Ahmadi |
| author_facet | Zohreh Rahimi Zainab Ahmadian Reza Akramipour Hamid Madani Hadi Mozafari Asad Vaisi-Raygani Ali Shahriari-Ahmadi |
| author_sort | Zohreh Rahimi |
| collection | DOAJ |
| description | "nAbstract "n  "nIntroduction: Polymorphism in genes involved in folate metabolism may cotribute to the susceptibility to acute lymphoblastic leukemia (ALL). "nPatients and Methods: To examine the influence of polymorphism in thymidylate synthase (TS 28-bp repeat) and methionine synthase (MS A2756G) genes on the susceptibility to ALL, 73 children with ALL and 128 age and gender matched, unrelated healthy individuals from Kermanshah Province were studied. Detection of TS 28-bp repeat and MS A2756G polymorphisms were performed by PCR and PCR-RFLP, respectively. "nResults: The frequency of TS 2R allele in patients and controls were 41.5 and 38%, respectively (OR 1.4, 95%CI 0.76-2.56, P=0.27). The allelic frequency of G allele of MS was higher (25%) in patients compared with healthy subjects (23%) [OR 1.04, 95%CI 0.58-1.87, P=0.8]. Considering MS AA and TS 3R3R genotypes as references indication where that individuals with MS GG+TS 2R2R genotypes have 1.3-fold increase risk of ALL (OR 1.3, 95%CI 0.6-2.7, P=0.5). "nConclusions: For the first time, our study has determined the frequency of polymorphism in two genes involved in the folate metabolism in a homogenous ethnic group of ALL patients. It seems that neither TS 28bp-repeat nor MS A2756G polymorphisms might be risk factors for susceptibility to ALL in western Iran. "n  "nKey words: ALL, Gene Polymorphism, MS A2756G, TS 28-bp Repeat, Western Iran |
| first_indexed | 2024-03-12T09:52:30Z |
| format | Article |
| id | doaj.art-b2598ebd43724b0f8bb09e392f1c883d |
| institution | Directory Open Access Journal |
| issn | 2008-3009 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T09:52:30Z |
| publishDate | 2010-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-b2598ebd43724b0f8bb09e392f1c883d2023-09-02T12:25:03ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072010-01-0141912Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western IranZohreh RahimiZainab AhmadianReza AkramipourHamid MadaniHadi MozafariAsad Vaisi-RayganiAli Shahriari-Ahmadi"nAbstract "n  "nIntroduction: Polymorphism in genes involved in folate metabolism may cotribute to the susceptibility to acute lymphoblastic leukemia (ALL). "nPatients and Methods: To examine the influence of polymorphism in thymidylate synthase (TS 28-bp repeat) and methionine synthase (MS A2756G) genes on the susceptibility to ALL, 73 children with ALL and 128 age and gender matched, unrelated healthy individuals from Kermanshah Province were studied. Detection of TS 28-bp repeat and MS A2756G polymorphisms were performed by PCR and PCR-RFLP, respectively. "nResults: The frequency of TS 2R allele in patients and controls were 41.5 and 38%, respectively (OR 1.4, 95%CI 0.76-2.56, P=0.27). The allelic frequency of G allele of MS was higher (25%) in patients compared with healthy subjects (23%) [OR 1.04, 95%CI 0.58-1.87, P=0.8]. Considering MS AA and TS 3R3R genotypes as references indication where that individuals with MS GG+TS 2R2R genotypes have 1.3-fold increase risk of ALL (OR 1.3, 95%CI 0.6-2.7, P=0.5). "nConclusions: For the first time, our study has determined the frequency of polymorphism in two genes involved in the folate metabolism in a homogenous ethnic group of ALL patients. It seems that neither TS 28bp-repeat nor MS A2756G polymorphisms might be risk factors for susceptibility to ALL in western Iran. "n  "nKey words: ALL, Gene Polymorphism, MS A2756G, TS 28-bp Repeat, Western Iranhttp://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17132.pdf&manuscript_id=17132 ALLGene PolymorphismMS A2756GTS 28-bp RepeatWestern Iran |
| spellingShingle | Zohreh Rahimi Zainab Ahmadian Reza Akramipour Hamid Madani Hadi Mozafari Asad Vaisi-Raygani Ali Shahriari-Ahmadi Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran International Journal of Hematology-Oncology and Stem Cell Research ALL Gene Polymorphism MS A2756G TS 28-bp Repeat Western Iran |
| title | Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran |
| title_full | Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran |
| title_fullStr | Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran |
| title_full_unstemmed | Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran |
| title_short | Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran |
| title_sort | thymidilate synthase and methionine synthase polymorphisms in children with acute lymphoblastic leukemia in western iran |
| topic | ALL Gene Polymorphism MS A2756G TS 28-bp Repeat Western Iran |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17132.pdf&manuscript_id=17132 |
| work_keys_str_mv | AT zohrehrahimi thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT zainabahmadian thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT rezaakramipour thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT hamidmadani thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT hadimozafari thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT asadvaisiraygani thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran AT alishahriariahmadi thymidilatesynthaseandmethioninesynthasepolymorphismsinchildrenwithacutelymphoblasticleukemiainwesterniran |