Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis
Abstract Background This study investigated patients' preference for allergy immunotherapy (AIT) administered as either sublingual immunotherapy‐tablets versus monthly or weekly subcutaneous immunotherapy (SCIT) from a Spanish patient perspective. Methods A discrete choice experiment (DCE) cons...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.12118 |
| _version_ | 1818536034426683392 |
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| author | Mette Bøgelund Ana Rosado Ingelmo Jose María Ausín Ruiz Adolfo Galán Vivó Henrik Brandi Mikkel Hasse Pedersen Anne Sofie Ledgaard Loftager Mark Aagren |
| author_facet | Mette Bøgelund Ana Rosado Ingelmo Jose María Ausín Ruiz Adolfo Galán Vivó Henrik Brandi Mikkel Hasse Pedersen Anne Sofie Ledgaard Loftager Mark Aagren |
| author_sort | Mette Bøgelund |
| collection | DOAJ |
| description | Abstract Background This study investigated patients' preference for allergy immunotherapy (AIT) administered as either sublingual immunotherapy‐tablets versus monthly or weekly subcutaneous immunotherapy (SCIT) from a Spanish patient perspective. Methods A discrete choice experiment (DCE) consisting of two blocks with eight choice sets in each was constructed to elicit the preferences for AIT. Three attributes were included in the DCE for the mode of administration, including the frequency of administration, the risk of systemic reactions and the co‐payment. Adults and caregivers of children with moderate to severe allergic rhinitis (AR) were included if they were not currently receiving or had not previously received AIT. Results In total, 587 adults and 613 caregivers started the survey. Of those, 579 adults and 611 caregivers completed the survey and were included in the study. Both adults and caregivers had a significant preference for tablets compared with both monthly and weekly injections (p ≤ 0.0001). Furthermore, the respondents showed a significant preference for reducing the risk of systemic reactions. Subgroup analyses showed that caregivers of polyallergic children and female caregivers were significantly less price sensitive when choosing their preferred treatment. Conclusion Our study demonstrated that both adults with AR and caregivers of children with AR prefer daily SLIT‐tablets to SCIT with either a weekly or monthly dose schedule. |
| first_indexed | 2024-12-11T18:32:47Z |
| format | Article |
| id | doaj.art-b259b082efd949e0a2471a42b30cc7cc |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-11T18:32:47Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-b259b082efd949e0a2471a42b30cc7cc2022-12-22T00:54:51ZengWileyClinical and Translational Allergy2045-70222022-02-01122n/an/a10.1002/clt2.12118Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitisMette Bøgelund0Ana Rosado Ingelmo1Jose María Ausín Ruiz2Adolfo Galán Vivó3Henrik Brandi4Mikkel Hasse Pedersen5Anne Sofie Ledgaard Loftager6Mark Aagren7Incentive Denmark Holte DenmarkAllergy Unit Hospital Universitario Fundación Alcorcón SpainAsociación Aire Libre Granada SpainMarket Access ALK‐Abelló, S.A. Madrid SpainGlobal Market Access & Public Affairs ALK Hørsholm DenmarkIncentive Denmark Holte DenmarkIncentive Denmark Holte DenmarkGlobal Market Access & Public Affairs ALK Hørsholm DenmarkAbstract Background This study investigated patients' preference for allergy immunotherapy (AIT) administered as either sublingual immunotherapy‐tablets versus monthly or weekly subcutaneous immunotherapy (SCIT) from a Spanish patient perspective. Methods A discrete choice experiment (DCE) consisting of two blocks with eight choice sets in each was constructed to elicit the preferences for AIT. Three attributes were included in the DCE for the mode of administration, including the frequency of administration, the risk of systemic reactions and the co‐payment. Adults and caregivers of children with moderate to severe allergic rhinitis (AR) were included if they were not currently receiving or had not previously received AIT. Results In total, 587 adults and 613 caregivers started the survey. Of those, 579 adults and 611 caregivers completed the survey and were included in the study. Both adults and caregivers had a significant preference for tablets compared with both monthly and weekly injections (p ≤ 0.0001). Furthermore, the respondents showed a significant preference for reducing the risk of systemic reactions. Subgroup analyses showed that caregivers of polyallergic children and female caregivers were significantly less price sensitive when choosing their preferred treatment. Conclusion Our study demonstrated that both adults with AR and caregivers of children with AR prefer daily SLIT‐tablets to SCIT with either a weekly or monthly dose schedule.https://doi.org/10.1002/clt2.12118allergische rhinitisdiscrete choice experimentpatientenpräferenzensubkutane immuntherapiesublinguale immuntherapie |
| spellingShingle | Mette Bøgelund Ana Rosado Ingelmo Jose María Ausín Ruiz Adolfo Galán Vivó Henrik Brandi Mikkel Hasse Pedersen Anne Sofie Ledgaard Loftager Mark Aagren Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis Clinical and Translational Allergy allergische rhinitis discrete choice experiment patientenpräferenzen subkutane immuntherapie sublinguale immuntherapie |
| title | Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis |
| title_full | Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis |
| title_fullStr | Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis |
| title_full_unstemmed | Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis |
| title_short | Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis |
| title_sort | preference for sublingual immunotherapy with tablets in a spanish population with allergic rhinitis |
| topic | allergische rhinitis discrete choice experiment patientenpräferenzen subkutane immuntherapie sublinguale immuntherapie |
| url | https://doi.org/10.1002/clt2.12118 |
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