The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects
Although it was known that obesity is an independent risk factor for metabolic disorders including diabetes, the factors that link these diseases were obscure. The Hedgehog-interacting protein (Hhip) is a negative regulator in tissue remodeling, and inhibits the proliferation of adipocytes, and prom...
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| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/742 |
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| author | Hsuan-Wen Chou Hao-Chang Hung Ching-Han Lin An-Chi Lin Ye-Fong Du Kai-Pi Cheng Chung-Hao Li Chih-Jen Chang Hung-Tsung Wu Horng-Yih Ou |
| author_facet | Hsuan-Wen Chou Hao-Chang Hung Ching-Han Lin An-Chi Lin Ye-Fong Du Kai-Pi Cheng Chung-Hao Li Chih-Jen Chang Hung-Tsung Wu Horng-Yih Ou |
| author_sort | Hsuan-Wen Chou |
| collection | DOAJ |
| description | Although it was known that obesity is an independent risk factor for metabolic disorders including diabetes, the factors that link these diseases were obscure. The Hedgehog-interacting protein (Hhip) is a negative regulator in tissue remodeling, and inhibits the proliferation of adipocytes, and promotes their differentiation. In addition, Hhip was positively associated with diabetes. However, the relationship between Hhip and obesity in the human body remains unclear. An analysis of the relationship between Hhip and normal weight, overweight, and obesity levels. Participants receiving a physical checkup were recruited. Anthropometric and biochemical data were collected. Serum Hhip levels were determined by enzyme-linked immunosorbent assay (ELISA). Subjects were classified into normal-weight, overweight, and obese groups based on their body mass index (BMI). The association between Hhip and obesity was examined by multivariate linear regression analysis. In total, 294 subjects who were either of a normal weight (<i>n</i> = 166), overweight (<i>n</i> = 90), or obese (<i>n</i> = 38) were enrolled. Hhip concentrations were 6.51 ± 4.86 ng/mL, 5.79 ± 4.33 ng/mL, and 3.97 ± 3.4 ng/mL in normal-weight, overweight, and obese groups, respectively (<i>p</i> for trend = 0.032). Moreover, the regression analysis showed that BMI (β = −0.144, 95% confidence interval (CI) = −0.397−0.046, <i>p =</i> 0.013) was negatively associated with Hhip concentrations after adjusting for sex and age. Being overweight (β = −0.181, 95% CI = −3.311−0.400, <i>p =</i> 0.013) and obese (β = −0.311, 95% CI = −6.393−2.384, <i>p</i> < 0.001) were independently associated with Hhip concentrations after adjusting for sex, age, fasting plasma glucose, the insulin level, and other cardiometabolic risk factors. Our results showed that overweight and obese subjects had lower Hhip concentrations than those of normal weight. Being overweight and obese were negatively associated with Hhip concentrations. Hhip might be a link between obesity and diabetes. |
| first_indexed | 2024-03-09T00:55:57Z |
| format | Article |
| id | doaj.art-b25a5f912d1244b496f67645a86184af |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:55:57Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b25a5f912d1244b496f67645a86184af2023-12-11T16:54:18ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110474210.3390/jcm10040742The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese SubjectsHsuan-Wen Chou0Hao-Chang Hung1Ching-Han Lin2An-Chi Lin3Ye-Fong Du4Kai-Pi Cheng5Chung-Hao Li6Chih-Jen Chang7Hung-Tsung Wu8Horng-Yih Ou9Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDepartment of Health Management Center, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, TaiwanDepartment of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanGraduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanAlthough it was known that obesity is an independent risk factor for metabolic disorders including diabetes, the factors that link these diseases were obscure. The Hedgehog-interacting protein (Hhip) is a negative regulator in tissue remodeling, and inhibits the proliferation of adipocytes, and promotes their differentiation. In addition, Hhip was positively associated with diabetes. However, the relationship between Hhip and obesity in the human body remains unclear. An analysis of the relationship between Hhip and normal weight, overweight, and obesity levels. Participants receiving a physical checkup were recruited. Anthropometric and biochemical data were collected. Serum Hhip levels were determined by enzyme-linked immunosorbent assay (ELISA). Subjects were classified into normal-weight, overweight, and obese groups based on their body mass index (BMI). The association between Hhip and obesity was examined by multivariate linear regression analysis. In total, 294 subjects who were either of a normal weight (<i>n</i> = 166), overweight (<i>n</i> = 90), or obese (<i>n</i> = 38) were enrolled. Hhip concentrations were 6.51 ± 4.86 ng/mL, 5.79 ± 4.33 ng/mL, and 3.97 ± 3.4 ng/mL in normal-weight, overweight, and obese groups, respectively (<i>p</i> for trend = 0.032). Moreover, the regression analysis showed that BMI (β = −0.144, 95% confidence interval (CI) = −0.397−0.046, <i>p =</i> 0.013) was negatively associated with Hhip concentrations after adjusting for sex and age. Being overweight (β = −0.181, 95% CI = −3.311−0.400, <i>p =</i> 0.013) and obese (β = −0.311, 95% CI = −6.393−2.384, <i>p</i> < 0.001) were independently associated with Hhip concentrations after adjusting for sex, age, fasting plasma glucose, the insulin level, and other cardiometabolic risk factors. Our results showed that overweight and obese subjects had lower Hhip concentrations than those of normal weight. Being overweight and obese were negatively associated with Hhip concentrations. Hhip might be a link between obesity and diabetes.https://www.mdpi.com/2077-0383/10/4/742hedgehog-interacting proteinimpaired fasting glucoseimpaired glucose tolerancenewly diagnosed diabetesnormal glucose tolerance |
| spellingShingle | Hsuan-Wen Chou Hao-Chang Hung Ching-Han Lin An-Chi Lin Ye-Fong Du Kai-Pi Cheng Chung-Hao Li Chih-Jen Chang Hung-Tsung Wu Horng-Yih Ou The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects Journal of Clinical Medicine hedgehog-interacting protein impaired fasting glucose impaired glucose tolerance newly diagnosed diabetes normal glucose tolerance |
| title | The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects |
| title_full | The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects |
| title_fullStr | The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects |
| title_full_unstemmed | The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects |
| title_short | The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects |
| title_sort | serum concentrations of hedgehog interacting protein a novel biomarker were decreased in overweight or obese subjects |
| topic | hedgehog-interacting protein impaired fasting glucose impaired glucose tolerance newly diagnosed diabetes normal glucose tolerance |
| url | https://www.mdpi.com/2077-0383/10/4/742 |
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