Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer
Abstract A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. Brain metastases pose a clinical ch...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-023-00550-1 |
| _version_ | 1797426941833248768 |
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| author | Stefania Morganti Heather A. Parsons Nancy U. Lin Albert Grinshpun |
| author_facet | Stefania Morganti Heather A. Parsons Nancy U. Lin Albert Grinshpun |
| author_sort | Stefania Morganti |
| collection | DOAJ |
| description | Abstract A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. Brain metastases pose a clinical challenge in diagnosis, treatment, and monitoring across all breast cancer subtypes, and better tools are needed. Liquid biopsy, which enables minimally invasive sampling of a patient’s cancer, has the potential to shed light on intra-cranial tumor biology and to improve patient care by enabling therapy tailoring. Here we review current evidence for the clinical validity of liquid biopsy in patients with breast cancer brain metastases, with a focus on circulating tumor cells and circulating tumor DNA. |
| first_indexed | 2024-03-09T08:37:08Z |
| format | Article |
| id | doaj.art-b25be7c61223472fac2495fedc11c2d9 |
| institution | Directory Open Access Journal |
| issn | 2374-4677 |
| language | English |
| last_indexed | 2024-03-09T08:37:08Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj.art-b25be7c61223472fac2495fedc11c2d92023-12-02T17:58:59ZengNature Portfolionpj Breast Cancer2374-46772023-05-01911910.1038/s41523-023-00550-1Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancerStefania Morganti0Heather A. Parsons1Nancy U. Lin2Albert Grinshpun3Medical Oncology, Dana-Farber Cancer InstituteMedical Oncology, Dana-Farber Cancer InstituteMedical Oncology, Dana-Farber Cancer InstituteMedical Oncology, Dana-Farber Cancer InstituteAbstract A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. Brain metastases pose a clinical challenge in diagnosis, treatment, and monitoring across all breast cancer subtypes, and better tools are needed. Liquid biopsy, which enables minimally invasive sampling of a patient’s cancer, has the potential to shed light on intra-cranial tumor biology and to improve patient care by enabling therapy tailoring. Here we review current evidence for the clinical validity of liquid biopsy in patients with breast cancer brain metastases, with a focus on circulating tumor cells and circulating tumor DNA.https://doi.org/10.1038/s41523-023-00550-1 |
| spellingShingle | Stefania Morganti Heather A. Parsons Nancy U. Lin Albert Grinshpun Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer npj Breast Cancer |
| title | Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| title_full | Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| title_fullStr | Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| title_full_unstemmed | Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| title_short | Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| title_sort | liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer |
| url | https://doi.org/10.1038/s41523-023-00550-1 |
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