A Rare Genetic Defect of MBL2 Increased the Risk for Progression of IgA Nephropathy

A Rare Genetic Defect of MBL2 Increased the Risk for Progression of IgA Nephropathy

The aim of this study was to investigate the association between lectin pathway-related genetic variations and progression in IgA nephropathy. Biopsy-proven IgAN patients with eGFR ≥15 ml/min/1.73 m2 at baseline and a minimum follow-up of 12-months were enrolled. A total of 1,007 patients and 121 he...

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Main Authors: Yan Ouyang, Li Zhu, Manman Shi, Shuwen Yu, Yuanmeng Jin, Zhaohui Wang, Jun Ma, Meng Yang, Xiaoyan Zhang, Xiaoxia Pan, Hong Ren, Weiming Wang, Hong Zhang, Jingyuan Xie, Nan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
complement lectin pathway
genetic variations
IgA nephropathy
disease progression
deregulated complement activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00537/full

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