Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis
Abstract Background Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent. We sought out to examine the potential role of PAI-1 as a marker for major adverse cardiovascular events (MACE). Method...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12959-018-0166-4 |
| _version_ | 1811270321216421888 |
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| author | Richard G. Jung Pouya Motazedian F. Daniel Ramirez Trevor Simard Pietro Di Santo Sarah Visintini Mohammad Ali Faraz Alisha Labinaz Young Jung Benjamin Hibbert |
| author_facet | Richard G. Jung Pouya Motazedian F. Daniel Ramirez Trevor Simard Pietro Di Santo Sarah Visintini Mohammad Ali Faraz Alisha Labinaz Young Jung Benjamin Hibbert |
| author_sort | Richard G. Jung |
| collection | DOAJ |
| description | Abstract Background Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent. We sought out to examine the potential role of PAI-1 as a marker for major adverse cardiovascular events (MACE). Methods We systematically reviewed all indexed studies examining the association between PAI-1 and MACE (defined as death, myocardial infarction, or cerebrovascular accident) or restenosis. EMBASE, Web of Science, Medline, and the Cochrane Library were searched through October 2016 to identify relevant studies, supplemented by letters to authors and review of citations. Studies reporting the results of PAI-1 antigen and/or activity levels in association with MACE in human subjects were included. Results Of 5961 articles screened, we identified 38 articles published between 1991 to 2016 that reported PAI-1 levels in 11,557 patients. In studies that examined PAI-1 antigen and activity levels, 15.1% and 29.6% of patients experienced MACE, respectively. Patients with MACE had higher PAI-1 antigen levels with a mean difference of 6.11 ng/mL (95% CI, 3.27-8.96). This finding was similar among patients with and without known coronary artery disease. Comparatively, studies that stratified by PAI-1 activity levels were not associated with MACE. In contrast, studies of coronary restenosis suggest PAI-1 antigen and activity levels are negatively associated with MACE. Conclusions Elevated plasma PAI-1 antigen levels are associated with MACE. Definitive studies are needed to ascertain if PAI-1 acts simply as a marker of risk or if it is indeed a bona fide therapeutic target. |
| first_indexed | 2024-04-12T21:59:14Z |
| format | Article |
| id | doaj.art-b25dcf2550db4fb5bc0c6cf8ed5df85d |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-12T21:59:14Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-b25dcf2550db4fb5bc0c6cf8ed5df85d2022-12-22T03:15:11ZengBMCThrombosis Journal1477-95602018-06-0116111210.1186/s12959-018-0166-4Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysisRichard G. Jung0Pouya Motazedian1F. Daniel Ramirez2Trevor Simard3Pietro Di Santo4Sarah Visintini5Mohammad Ali Faraz6Alisha Labinaz7Young Jung8Benjamin Hibbert9CAPITAL Research Group, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteBerkman Library, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteCAPITAL Research Group, University of Ottawa Heart InstituteDepartment of Health Research Methods, Evidence, and Impact, McMaster UniversityCAPITAL Research Group, University of Ottawa Heart InstituteAbstract Background Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent. We sought out to examine the potential role of PAI-1 as a marker for major adverse cardiovascular events (MACE). Methods We systematically reviewed all indexed studies examining the association between PAI-1 and MACE (defined as death, myocardial infarction, or cerebrovascular accident) or restenosis. EMBASE, Web of Science, Medline, and the Cochrane Library were searched through October 2016 to identify relevant studies, supplemented by letters to authors and review of citations. Studies reporting the results of PAI-1 antigen and/or activity levels in association with MACE in human subjects were included. Results Of 5961 articles screened, we identified 38 articles published between 1991 to 2016 that reported PAI-1 levels in 11,557 patients. In studies that examined PAI-1 antigen and activity levels, 15.1% and 29.6% of patients experienced MACE, respectively. Patients with MACE had higher PAI-1 antigen levels with a mean difference of 6.11 ng/mL (95% CI, 3.27-8.96). This finding was similar among patients with and without known coronary artery disease. Comparatively, studies that stratified by PAI-1 activity levels were not associated with MACE. In contrast, studies of coronary restenosis suggest PAI-1 antigen and activity levels are negatively associated with MACE. Conclusions Elevated plasma PAI-1 antigen levels are associated with MACE. Definitive studies are needed to ascertain if PAI-1 acts simply as a marker of risk or if it is indeed a bona fide therapeutic target.http://link.springer.com/article/10.1186/s12959-018-0166-4Plasminogen activator inhibitor-1BiomarkersMortalityMyocardial infarctionMeta-analysis |
| spellingShingle | Richard G. Jung Pouya Motazedian F. Daniel Ramirez Trevor Simard Pietro Di Santo Sarah Visintini Mohammad Ali Faraz Alisha Labinaz Young Jung Benjamin Hibbert Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis Thrombosis Journal Plasminogen activator inhibitor-1 Biomarkers Mortality Myocardial infarction Meta-analysis |
| title | Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis |
| title_full | Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis |
| title_fullStr | Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis |
| title_full_unstemmed | Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis |
| title_short | Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis |
| title_sort | association between plasminogen activator inhibitor 1 and cardiovascular events a systematic review and meta analysis |
| topic | Plasminogen activator inhibitor-1 Biomarkers Mortality Myocardial infarction Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12959-018-0166-4 |
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