Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration
Abstract Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular degeneration (AMD). AMD, as one of the most common causes of irreversible visual impairment worldwide, remains in need of an appropriate approach to restore retinal function. Wet AMD, which is characterized...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-05-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02894-0 |
| _version_ | 1818207901955653632 |
|---|---|
| author | Samaneh Dehghan Reza Mirshahi Alireza Shoae-Hassani Masood Naseripour |
| author_facet | Samaneh Dehghan Reza Mirshahi Alireza Shoae-Hassani Masood Naseripour |
| author_sort | Samaneh Dehghan |
| collection | DOAJ |
| description | Abstract Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular degeneration (AMD). AMD, as one of the most common causes of irreversible visual impairment worldwide, remains in need of an appropriate approach to restore retinal function. Wet AMD, which is characterized by neovascular formation, can be stabilized by currently available therapies, including laser photocoagulation, photodynamic therapy, and intraocular injections of anti-VEFG (anti-vascular endothelial growth factor) therapy or a combination of these modalities. Unlike wet AMD, there is no effective therapy for progressive dry (non-neovascular) AMD. However, stem cell-based therapies, a part of regenerative medicine, have shown promising results for retinal degenerative diseases such as AMD. The goal of RPE cell therapy is to return the normal structure and function of the retina by re-establishing its interaction with photoreceptors, which is essential to vision. Considering the limited source of naturally occurring RPE cells, recent progress in stem cell research has allowed the generation of RPE cells from human pluripotent cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC). Since iPSCs face neither ethical arguments nor significant immunological considerations when compared to ESCs, they open a new horizon for cell therapy of AMD. The current study aims to discuss AMD, review the protocols for making human iPSCs-derived RPEs, and summarize recent developments in the field of iPSC-derived RPEs cell therapy. |
| first_indexed | 2024-12-12T04:36:17Z |
| format | Article |
| id | doaj.art-b25e36f1660f45bb81d020234022f208 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-12T04:36:17Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-b25e36f1660f45bb81d020234022f2082022-12-22T00:37:57ZengBMCStem Cell Research & Therapy1757-65122022-05-0113111910.1186/s13287-022-02894-0Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degenerationSamaneh Dehghan0Reza Mirshahi1Alireza Shoae-Hassani2Masood Naseripour3Stem Cell and Regenerative Medicine Research Center, Iran University of Medical SciencesEye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical SciencesStem Cell and Regenerative Medicine Research Center, Iran University of Medical SciencesStem Cell and Regenerative Medicine Research Center, Iran University of Medical SciencesAbstract Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular degeneration (AMD). AMD, as one of the most common causes of irreversible visual impairment worldwide, remains in need of an appropriate approach to restore retinal function. Wet AMD, which is characterized by neovascular formation, can be stabilized by currently available therapies, including laser photocoagulation, photodynamic therapy, and intraocular injections of anti-VEFG (anti-vascular endothelial growth factor) therapy or a combination of these modalities. Unlike wet AMD, there is no effective therapy for progressive dry (non-neovascular) AMD. However, stem cell-based therapies, a part of regenerative medicine, have shown promising results for retinal degenerative diseases such as AMD. The goal of RPE cell therapy is to return the normal structure and function of the retina by re-establishing its interaction with photoreceptors, which is essential to vision. Considering the limited source of naturally occurring RPE cells, recent progress in stem cell research has allowed the generation of RPE cells from human pluripotent cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC). Since iPSCs face neither ethical arguments nor significant immunological considerations when compared to ESCs, they open a new horizon for cell therapy of AMD. The current study aims to discuss AMD, review the protocols for making human iPSCs-derived RPEs, and summarize recent developments in the field of iPSC-derived RPEs cell therapy.https://doi.org/10.1186/s13287-022-02894-0Cell therapyAge-related macular degenerationRetinal pigmented epitheliumInduced pluripotent stem cellsRetinaClinical trial |
| spellingShingle | Samaneh Dehghan Reza Mirshahi Alireza Shoae-Hassani Masood Naseripour Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration Stem Cell Research & Therapy Cell therapy Age-related macular degeneration Retinal pigmented epithelium Induced pluripotent stem cells Retina Clinical trial |
| title | Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration |
| title_full | Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration |
| title_fullStr | Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration |
| title_full_unstemmed | Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration |
| title_short | Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration |
| title_sort | human induced pluripotent stem cells derived retinal pigmented epithelium a new horizon for cells based therapies for age related macular degeneration |
| topic | Cell therapy Age-related macular degeneration Retinal pigmented epithelium Induced pluripotent stem cells Retina Clinical trial |
| url | https://doi.org/10.1186/s13287-022-02894-0 |
| work_keys_str_mv | AT samanehdehghan humaninducedpluripotentstemcellsderivedretinalpigmentedepitheliumanewhorizonforcellsbasedtherapiesforagerelatedmaculardegeneration AT rezamirshahi humaninducedpluripotentstemcellsderivedretinalpigmentedepitheliumanewhorizonforcellsbasedtherapiesforagerelatedmaculardegeneration AT alirezashoaehassani humaninducedpluripotentstemcellsderivedretinalpigmentedepitheliumanewhorizonforcellsbasedtherapiesforagerelatedmaculardegeneration AT masoodnaseripour humaninducedpluripotentstemcellsderivedretinalpigmentedepitheliumanewhorizonforcellsbasedtherapiesforagerelatedmaculardegeneration |