An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention
Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections and promoting bacterial survival within the host. In recent years, there has been a growing interest in discovering new...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/2/162 |
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| author | Tsvetozara Damyanova Petya D. Dimitrova Dayana Borisova Tanya Topouzova-Hristova Emi Haladjova Tsvetelina Paunova-Krasteva |
| author_facet | Tsvetozara Damyanova Petya D. Dimitrova Dayana Borisova Tanya Topouzova-Hristova Emi Haladjova Tsvetelina Paunova-Krasteva |
| author_sort | Tsvetozara Damyanova |
| collection | DOAJ |
| description | Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections and promoting bacterial survival within the host. In recent years, there has been a growing interest in discovering new compounds capable of inhibiting biofilm formation. This is considered a promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They should be structurally unique, enable easy entry into cells, influence quorum sensing signaling, and synergize with other antibacterial agents. Many of these properties are found in both natural systems that are isolated from plants and in synthetic systems like nanoparticles and nanocomposites. In this review, we discuss the clinical nature of biofilm-associated infections and some of the mechanisms associated with their antibiotic tolerance. We focus on the advantages and efficacy of various natural and synthetic compounds as a new therapeutic approach to control bacterial biofilms and address multidrug resistance in bacteria. |
| first_indexed | 2024-03-07T22:18:11Z |
| format | Article |
| id | doaj.art-b25eb57e3edd4ca88b4dd579ce76b3e5 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:18:11Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b25eb57e3edd4ca88b4dd579ce76b3e52024-02-23T15:30:57ZengMDPI AGPharmaceutics1999-49232024-01-0116216210.3390/pharmaceutics16020162An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and PreventionTsvetozara Damyanova0Petya D. Dimitrova1Dayana Borisova2Tanya Topouzova-Hristova3Emi Haladjova4Tsvetelina Paunova-Krasteva5Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St. bl. 26, 1113 Sofia, BulgariaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St. bl. 26, 1113 Sofia, BulgariaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St. bl. 26, 1113 Sofia, BulgariaFaculty of Biology, Sofia University “St. K. Ohridski”, 8 D. Tsankov Blvd., 1164 Sofia, BulgariaInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St. bl. 103-A, 1113 Sofia, BulgariaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St. bl. 26, 1113 Sofia, BulgariaBiofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections and promoting bacterial survival within the host. In recent years, there has been a growing interest in discovering new compounds capable of inhibiting biofilm formation. This is considered a promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They should be structurally unique, enable easy entry into cells, influence quorum sensing signaling, and synergize with other antibacterial agents. Many of these properties are found in both natural systems that are isolated from plants and in synthetic systems like nanoparticles and nanocomposites. In this review, we discuss the clinical nature of biofilm-associated infections and some of the mechanisms associated with their antibiotic tolerance. We focus on the advantages and efficacy of various natural and synthetic compounds as a new therapeutic approach to control bacterial biofilms and address multidrug resistance in bacteria.https://www.mdpi.com/1999-4923/16/2/162biofilmsbiofilm-associated infectionsnanomaterialsphytochemicals |
| spellingShingle | Tsvetozara Damyanova Petya D. Dimitrova Dayana Borisova Tanya Topouzova-Hristova Emi Haladjova Tsvetelina Paunova-Krasteva An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention Pharmaceutics biofilms biofilm-associated infections nanomaterials phytochemicals |
| title | An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention |
| title_full | An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention |
| title_fullStr | An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention |
| title_full_unstemmed | An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention |
| title_short | An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention |
| title_sort | overview of biofilm associated infections and the role of phytochemicals and nanomaterials in their control and prevention |
| topic | biofilms biofilm-associated infections nanomaterials phytochemicals |
| url | https://www.mdpi.com/1999-4923/16/2/162 |
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