Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5058 |
| _version_ | 1797512309578399744 |
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| author | Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz |
| author_facet | Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz |
| author_sort | Andrzej Obojski |
| collection | DOAJ |
| description | Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Methods: There were 10 patients with SA-PAL, 11 patients with COPD, and 10 healthy volunteers (HV) enrolled in this study. The patients were examined with a 128-multislice scanner at full inspiration. Measurements were taken from the third to ninth bronchial generations. Results: The thickness of the bronchial wall was greater in the SA-PAL than in the COPD group for most bronchial generations (<i>p</i> < 0.05). The mean lung density was the lowest in the SA-PAL group (−846 HU), followed by the COPD group (−836 HU), with no statistical difference between these two groups. The low-attenuation volume percentage (LAV% < −950 HU) was significantly higher in the SA-PAL group (15.8%) and COPD group (10.4%) compared with the HV group (7%) (<i>p</i> = 0.03). Conclusion: Severe asthma with persistent airflow limitation and COPD become similar with time within the functional and morphological dimensions. Emphysema qualities are present in COPD and in SA-PAL patients. |
| first_indexed | 2024-03-10T06:00:02Z |
| format | Article |
| id | doaj.art-b25ebfab6f4a4669a1656047e70b9cf2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:00:02Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b25ebfab6f4a4669a1656047e70b9cf22023-11-22T21:06:41ZengMDPI AGJournal of Clinical Medicine2077-03832021-10-011021505810.3390/jcm10215058Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary DiseaseAndrzej Obojski0Mateusz Patyk1Urszula Zaleska-Dorobisz2Department of Internal Diseases, Pneumonology and Allergology, Wroclaw Medical University, 50-369 Wrocław, PolandDepartment of General and Pediatric Radiology, Wroclaw Medical University, 50-369 Wrocław, PolandDepartment of General and Pediatric Radiology, Wroclaw Medical University, 50-369 Wrocław, PolandBackground: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Methods: There were 10 patients with SA-PAL, 11 patients with COPD, and 10 healthy volunteers (HV) enrolled in this study. The patients were examined with a 128-multislice scanner at full inspiration. Measurements were taken from the third to ninth bronchial generations. Results: The thickness of the bronchial wall was greater in the SA-PAL than in the COPD group for most bronchial generations (<i>p</i> < 0.05). The mean lung density was the lowest in the SA-PAL group (−846 HU), followed by the COPD group (−836 HU), with no statistical difference between these two groups. The low-attenuation volume percentage (LAV% < −950 HU) was significantly higher in the SA-PAL group (15.8%) and COPD group (10.4%) compared with the HV group (7%) (<i>p</i> = 0.03). Conclusion: Severe asthma with persistent airflow limitation and COPD become similar with time within the functional and morphological dimensions. Emphysema qualities are present in COPD and in SA-PAL patients.https://www.mdpi.com/2077-0383/10/21/5058asthmachronic obstructive pulmonary diseaseairway remodellingemphysemaquantitative computed tomography |
| spellingShingle | Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease Journal of Clinical Medicine asthma chronic obstructive pulmonary disease airway remodelling emphysema quantitative computed tomography |
| title | Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease |
| title_full | Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease |
| title_fullStr | Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease |
| title_short | Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease |
| title_sort | similarities in quantitative computed tomography imaging of the lung in severe asthma with persistent airflow limitation and chronic obstructive pulmonary disease |
| topic | asthma chronic obstructive pulmonary disease airway remodelling emphysema quantitative computed tomography |
| url | https://www.mdpi.com/2077-0383/10/21/5058 |
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