Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine
Introduction: Sialorrhoea, or excessive salivation, is common in psychiatric patients. This can be distressing because of its physical and psychosocial complications. Sialorrhoea due to psychotropic drugs has been reported repeatedly in the literature. Clozapine is the antipsychotic most commonly as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Online Access: | https://doi.org/10.1177/02537176211025789 |
| _version_ | 1797962822185910272 |
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| author | Ankit Halder Navna Panchami Ravindran Parth Nagda Devavrat Harshe Gurudas Harshe |
| author_facet | Ankit Halder Navna Panchami Ravindran Parth Nagda Devavrat Harshe Gurudas Harshe |
| author_sort | Ankit Halder |
| collection | DOAJ |
| description | Introduction: Sialorrhoea, or excessive salivation, is common in psychiatric patients. This can be distressing because of its physical and psychosocial complications. Sialorrhoea due to psychotropic drugs has been reported repeatedly in the literature. Clozapine is the antipsychotic most commonly associated with sialorrhoea. Objective: The objective of this review was to examine and discuss the existing literature on all psychotropic drugs associated with sialorrhoea, except clozapine. Methods: Google Scholar and PubMed were searched for the literature on psychotropic-induced sialorrhoea. The search terms used were sialorrhoea, antidepressants, antipsychotics, mood stabilizer, and benzodiazepines. Case reports on patients suffering from psychotropic-induced sialorrhoea except clozapine are reviewed in this study. Results: The pathophysiology behind psychotropic-induced sialorrhoea, the population susceptible to sialorrhoea, and the exact duration from the start of sialorrhoea the drug course to the onset of sialorrhoea are unknown. Also, sialorrhoea is not associated with drug toxicity and is observed even in patients receiving normal doses of psychotropic medications. Treatment involves dose reduction, discontinuation of drugs responsible for the adverse effect, or adding anticholinergic drugs. Conclusion: Sialorrhoea due to clozapine has been reported in the literature. Many other antipsychotics, antidepressants such as sertraline, and other psychotropic drugs such as lithium have also been reported to cause sialorrhoea. No increase in the risk of sialorrhoea was seen in any of the age groups, and no association was found with treatment duration. In cases of lithium-induced sialorrhoea, no relationship was observed between serum levels of lithium and sialorrhoea. |
| first_indexed | 2024-04-11T01:19:49Z |
| format | Article |
| id | doaj.art-b25fde0181bc4e6a96f590a89bce2896 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 0975-1564 |
| language | English |
| last_indexed | 2024-04-11T01:19:49Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-b25fde0181bc4e6a96f590a89bce28962023-01-03T14:35:58ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71760975-15642023-01-014510.1177/02537176211025789Review of Psychotropic Agents Associated with Sialorrhoea, Except ClozapineAnkit Halder0Navna Panchami Ravindran1Parth Nagda2Devavrat Harshe3Gurudas Harshe4 Dept. of Psychiatry, D. Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur, Maharashtra, India. Dept. of Psychiatry, D. Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur, Maharashtra, India. Dept. of Psychiatry, D. Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur, Maharashtra, India. Dept. of Psychiatry, D. Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur, Maharashtra, India. Dept. of Psychiatry, D. Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur, Maharashtra, India.Introduction: Sialorrhoea, or excessive salivation, is common in psychiatric patients. This can be distressing because of its physical and psychosocial complications. Sialorrhoea due to psychotropic drugs has been reported repeatedly in the literature. Clozapine is the antipsychotic most commonly associated with sialorrhoea. Objective: The objective of this review was to examine and discuss the existing literature on all psychotropic drugs associated with sialorrhoea, except clozapine. Methods: Google Scholar and PubMed were searched for the literature on psychotropic-induced sialorrhoea. The search terms used were sialorrhoea, antidepressants, antipsychotics, mood stabilizer, and benzodiazepines. Case reports on patients suffering from psychotropic-induced sialorrhoea except clozapine are reviewed in this study. Results: The pathophysiology behind psychotropic-induced sialorrhoea, the population susceptible to sialorrhoea, and the exact duration from the start of sialorrhoea the drug course to the onset of sialorrhoea are unknown. Also, sialorrhoea is not associated with drug toxicity and is observed even in patients receiving normal doses of psychotropic medications. Treatment involves dose reduction, discontinuation of drugs responsible for the adverse effect, or adding anticholinergic drugs. Conclusion: Sialorrhoea due to clozapine has been reported in the literature. Many other antipsychotics, antidepressants such as sertraline, and other psychotropic drugs such as lithium have also been reported to cause sialorrhoea. No increase in the risk of sialorrhoea was seen in any of the age groups, and no association was found with treatment duration. In cases of lithium-induced sialorrhoea, no relationship was observed between serum levels of lithium and sialorrhoea.https://doi.org/10.1177/02537176211025789 |
| spellingShingle | Ankit Halder Navna Panchami Ravindran Parth Nagda Devavrat Harshe Gurudas Harshe Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine Indian Journal of Psychological Medicine |
| title | Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine |
| title_full | Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine |
| title_fullStr | Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine |
| title_full_unstemmed | Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine |
| title_short | Review of Psychotropic Agents Associated with Sialorrhoea, Except Clozapine |
| title_sort | review of psychotropic agents associated with sialorrhoea except clozapine |
| url | https://doi.org/10.1177/02537176211025789 |
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