MIR497HG‐Derived miR‐195 and miR‐497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer

MIR497HG‐Derived miR‐195 and miR‐497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer

Abstract Tamoxifen is commonly used for the treatment of patients with estrogen receptor‐positive (ER+) breast cancer, but the acquired resistance to tamoxifen presents a critical challenge of breast cancer therapeutics. Recently, long noncoding RNA MIR497HG and its embedded miR‐497 and miR‐195 are...

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Bibliographic Details
Main Authors: Yao Tian, Zhao‐Hui Chen, Peng Wu, Di Zhang, Yue Ma, Xiao‐Feng Liu, Xin Wang, Dan Ding, Xu‐Chen Cao, Yue Yu
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
breast cancer
miR‐497/195
MIR497HG
PI3K‐AKT
tamoxifen resistance
Online Access:https://doi.org/10.1002/advs.202204819

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