Recent advances in fabrication of dECM-based composite materials for skin tissue engineering
Chronic wound management is an intractable medical and social problem, affecting the health of millions worldwide. Decellularized extracellular matrix (dECM)-based materials possess remarkable biological properties for tissue regeneration, which have been used as commercial products for skin regener...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1348856/full |
| _version_ | 1797348575599919104 |
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| author | Peiyao Xu Peiyao Xu Jiutao Cao Jiutao Cao Youyu Duan Youyu Duan Ranjith Kumar Kankala Ranjith Kumar Kankala Aizheng Chen Aizheng Chen |
| author_facet | Peiyao Xu Peiyao Xu Jiutao Cao Jiutao Cao Youyu Duan Youyu Duan Ranjith Kumar Kankala Ranjith Kumar Kankala Aizheng Chen Aizheng Chen |
| author_sort | Peiyao Xu |
| collection | DOAJ |
| description | Chronic wound management is an intractable medical and social problem, affecting the health of millions worldwide. Decellularized extracellular matrix (dECM)-based materials possess remarkable biological properties for tissue regeneration, which have been used as commercial products for skin regeneration in clinics. However, the complex external environment and the longer chronic wound-healing process hinder the application of pure dECM materials. dECM-based composite materials are constructed to promote the healing process of different wounds, showing noteworthy functions, such as anti-microbial activity and suitable degradability. Moreover, fabrication technologies for designing wound dressings with various forms have expanded the application of dECM-based composite materials. This review provides a summary of the recent fabrication technologies for building dECM-based composite materials, highlighting advances in dECM-based molded hydrogels, electrospun fibers, and bio-printed scaffolds in managing wounds. The associated challenges and prospects in the clinical application of dECM-based composite materials for wound healing are finally discussed. |
| first_indexed | 2024-03-08T12:07:59Z |
| format | Article |
| id | doaj.art-b264c561de424f4c99d382c7a69dd949 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T12:07:59Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b264c561de424f4c99d382c7a69dd9492024-01-23T04:31:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011210.3389/fbioe.2024.13488561348856Recent advances in fabrication of dECM-based composite materials for skin tissue engineeringPeiyao Xu0Peiyao Xu1Jiutao Cao2Jiutao Cao3Youyu Duan4Youyu Duan5Ranjith Kumar Kankala6Ranjith Kumar Kankala7Aizheng Chen8Aizheng Chen9Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian, ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian, ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian, ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian, ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, Fujian, ChinaChronic wound management is an intractable medical and social problem, affecting the health of millions worldwide. Decellularized extracellular matrix (dECM)-based materials possess remarkable biological properties for tissue regeneration, which have been used as commercial products for skin regeneration in clinics. However, the complex external environment and the longer chronic wound-healing process hinder the application of pure dECM materials. dECM-based composite materials are constructed to promote the healing process of different wounds, showing noteworthy functions, such as anti-microbial activity and suitable degradability. Moreover, fabrication technologies for designing wound dressings with various forms have expanded the application of dECM-based composite materials. This review provides a summary of the recent fabrication technologies for building dECM-based composite materials, highlighting advances in dECM-based molded hydrogels, electrospun fibers, and bio-printed scaffolds in managing wounds. The associated challenges and prospects in the clinical application of dECM-based composite materials for wound healing are finally discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1348856/fulldECMskinwound healingcomposite materialstissue regeneration |
| spellingShingle | Peiyao Xu Peiyao Xu Jiutao Cao Jiutao Cao Youyu Duan Youyu Duan Ranjith Kumar Kankala Ranjith Kumar Kankala Aizheng Chen Aizheng Chen Recent advances in fabrication of dECM-based composite materials for skin tissue engineering Frontiers in Bioengineering and Biotechnology dECM skin wound healing composite materials tissue regeneration |
| title | Recent advances in fabrication of dECM-based composite materials for skin tissue engineering |
| title_full | Recent advances in fabrication of dECM-based composite materials for skin tissue engineering |
| title_fullStr | Recent advances in fabrication of dECM-based composite materials for skin tissue engineering |
| title_full_unstemmed | Recent advances in fabrication of dECM-based composite materials for skin tissue engineering |
| title_short | Recent advances in fabrication of dECM-based composite materials for skin tissue engineering |
| title_sort | recent advances in fabrication of decm based composite materials for skin tissue engineering |
| topic | dECM skin wound healing composite materials tissue regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1348856/full |
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