Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder
Abstract Background Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality. In this study, the relationship among childhood trauma, social support...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-024-05672-9 |
| _version_ | 1797219686293700608 |
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| author | Min Yang Jiaxin Li Yaqian Fu Guotao Wang Minghui Liu Jindong Chen Jieyu Liu |
| author_facet | Min Yang Jiaxin Li Yaqian Fu Guotao Wang Minghui Liu Jindong Chen Jieyu Liu |
| author_sort | Min Yang |
| collection | DOAJ |
| description | Abstract Background Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality. In this study, the relationship among childhood trauma, social support, and clinical symptoms of BD was investigated and the risk factors for suicidality were explored in female patients with BD. Methods This study included 57 drug-naive female BD patients, 64 female BD patients with long-term medication, and 50 age-matched female healthy controls. Childhood trauma, social support, clinical symptoms, cognition, and suicidality (suicide ideation, suicide plan, suicide attempt, suicide frequency) were measured with scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and suicidality, and lower levels of social support and cognitive deficits. In the drug-naïve BD group, social support mediated the relationship between childhood trauma and insomnia symptoms (indirect effect: ab = 0.025). In the BD with long-term medication group, mania symptom was associated with suicide plan (OR = 1.127, p = 0.030), childhood trauma was associated with suicide attempt (OR = 1.088, p = 0.018), and years of education (OR = 0.773, p = 0.028), childhood trauma (OR = 1.059, p = 0.009), and delayed memory (OR= 1.091, p= 0.016) was associated with suicide frequency (OR = 1.091, p = 0.016). Conclusions This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms in females with BD. Additionally, mania symptoms, childhood trauma, and delayed memory were risk factors for suicidality. Interventions providing social support and improving cognitive function may be beneficial for females with BD who are exposed to childhood trauma and with high suicide risk. |
| first_indexed | 2024-04-24T12:37:35Z |
| format | Article |
| id | doaj.art-b264fe16e28a44bfb7159b8355d256ba |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-24T12:37:35Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-b264fe16e28a44bfb7159b8355d256ba2024-04-07T11:26:38ZengBMCBMC Psychiatry1471-244X2024-04-0124111010.1186/s12888-024-05672-9Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorderMin Yang0Jiaxin Li1Yaqian Fu2Guotao Wang3Minghui Liu4Jindong Chen5Jieyu Liu6Department of Psychiatry, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South UniversityDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South UniversityDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South UniversityAbstract Background Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality. In this study, the relationship among childhood trauma, social support, and clinical symptoms of BD was investigated and the risk factors for suicidality were explored in female patients with BD. Methods This study included 57 drug-naive female BD patients, 64 female BD patients with long-term medication, and 50 age-matched female healthy controls. Childhood trauma, social support, clinical symptoms, cognition, and suicidality (suicide ideation, suicide plan, suicide attempt, suicide frequency) were measured with scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and suicidality, and lower levels of social support and cognitive deficits. In the drug-naïve BD group, social support mediated the relationship between childhood trauma and insomnia symptoms (indirect effect: ab = 0.025). In the BD with long-term medication group, mania symptom was associated with suicide plan (OR = 1.127, p = 0.030), childhood trauma was associated with suicide attempt (OR = 1.088, p = 0.018), and years of education (OR = 0.773, p = 0.028), childhood trauma (OR = 1.059, p = 0.009), and delayed memory (OR= 1.091, p= 0.016) was associated with suicide frequency (OR = 1.091, p = 0.016). Conclusions This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms in females with BD. Additionally, mania symptoms, childhood trauma, and delayed memory were risk factors for suicidality. Interventions providing social support and improving cognitive function may be beneficial for females with BD who are exposed to childhood trauma and with high suicide risk.https://doi.org/10.1186/s12888-024-05672-9Bipolar disorderFemaleChildhood traumaSocial supportCognitionSuicidality |
| spellingShingle | Min Yang Jiaxin Li Yaqian Fu Guotao Wang Minghui Liu Jindong Chen Jieyu Liu Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder BMC Psychiatry Bipolar disorder Female Childhood trauma Social support Cognition Suicidality |
| title | Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder |
| title_full | Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder |
| title_fullStr | Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder |
| title_full_unstemmed | Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder |
| title_short | Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder |
| title_sort | association of childhood trauma social support cognition and suicidality in females with bipolar disorder |
| topic | Bipolar disorder Female Childhood trauma Social support Cognition Suicidality |
| url | https://doi.org/10.1186/s12888-024-05672-9 |
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