Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar
Ventricular arrhythmias after heart attack are a leading cause of death. Here the authors show, in a porcine model, that KCNE3 and KCNE4 upregulation and a unique pattern of repolarization heterogeneity in the scar facilitate reentrant ventricular tachycardia.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28418-1 |
| _version_ | 1818330678998073344 |
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| author | Kamilla Kelemen Ian D. Greener Xiaoping Wan Shankar Parajuli J. Kevin Donahue |
| author_facet | Kamilla Kelemen Ian D. Greener Xiaoping Wan Shankar Parajuli J. Kevin Donahue |
| author_sort | Kamilla Kelemen |
| collection | DOAJ |
| description | Ventricular arrhythmias after heart attack are a leading cause of death. Here the authors show, in a porcine model, that KCNE3 and KCNE4 upregulation and a unique pattern of repolarization heterogeneity in the scar facilitate reentrant ventricular tachycardia. |
| first_indexed | 2024-12-13T13:07:47Z |
| format | Article |
| id | doaj.art-b266107708554e1cbe599481b6c4a68b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T13:07:47Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b266107708554e1cbe599481b6c4a68b2022-12-21T23:44:47ZengNature PortfolioNature Communications2041-17232022-02-0113111410.1038/s41467-022-28418-1Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scarKamilla Kelemen0Ian D. Greener1Xiaoping Wan2Shankar Parajuli3J. Kevin Donahue4Heart and Vascular Research Center, MetroHealth Medical Center, Case Western Reserve UniversityHeart and Vascular Research Center, MetroHealth Medical Center, Case Western Reserve UniversityHeart and Vascular Research Center, MetroHealth Medical Center, Case Western Reserve UniversityDivision of Cardiology, University of Massachusetts Medical SchoolDivision of Cardiology, University of Massachusetts Medical SchoolVentricular arrhythmias after heart attack are a leading cause of death. Here the authors show, in a porcine model, that KCNE3 and KCNE4 upregulation and a unique pattern of repolarization heterogeneity in the scar facilitate reentrant ventricular tachycardia.https://doi.org/10.1038/s41467-022-28418-1 |
| spellingShingle | Kamilla Kelemen Ian D. Greener Xiaoping Wan Shankar Parajuli J. Kevin Donahue Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar Nature Communications |
| title | Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| title_full | Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| title_fullStr | Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| title_full_unstemmed | Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| title_short | Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| title_sort | heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar |
| url | https://doi.org/10.1038/s41467-022-28418-1 |
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