A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment

A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment

ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response. CD39, also known as Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), can hydrolyze ATP into ADP and AMP, then...

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Bibliographic Details
Main Authors: Zheng Wei, Fang Ren, Shiyong Gong, Beilei Shi, Kedong Ouyang, Chengbin Wu
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Medicine in Drug Discovery
Subjects:
CD39
ATP
Adenosine
Xenograft
mAb
Tumor
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098621000142

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