The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis
Background: To investigate the impact of COVID-19 outbreak on the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). Methods: A retrospective analysis was performed using an Italian multi-institutional database of TURBT patients with high-risk urothelial NMIBC between January 201...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5276 |
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| author | Matteo Ferro Francesco Del Giudice Giuseppe Carrieri Gian Maria Busetto Luigi Cormio Rodolfo Hurle Roberto Contieri Davide Arcaniolo Alessandro Sciarra Martina Maggi Francesco Porpiglia Matteo Manfredi Cristian Fiori Alessandro Antonelli Alessandro Tafuri Pierluigi Bove Carlo Terrone Marco Borghesi Elisabetta Costantini Ester Iliano Emanuele Montanari Luca Boeri Giorgio Ivan Russo Massimo Madonia Alessandro Tedde Alessandro Veccia Claudio Simeone Giovanni Liguori Carlo Trombetta Eugenio Brunocilla Riccardo Schiavina Fabrizio Dal Moro Marco Racioppi Mihai Dorin Vartolomei Nicola Longo Lorenzo Spirito Felice Crocetto Francesco Cantiello Rocco Damiano Savino M. Di Stasi Michele Marchioni Luigi Schips Paolo Parma Luca Carmignani Andrea Conti Francesco Soria Paolo Gontero Biagio Barone Federico Deho Emanuele Zaffuto Rocco Papalia Roberto M. Scarpa Vincenzo Pagliarulo Giuseppe Lucarelli Pasquale Ditonno Francesco Maria Gerardo Botticelli Gennaro Musi Michele Catellani Ottavio de Cobelli |
| author_facet | Matteo Ferro Francesco Del Giudice Giuseppe Carrieri Gian Maria Busetto Luigi Cormio Rodolfo Hurle Roberto Contieri Davide Arcaniolo Alessandro Sciarra Martina Maggi Francesco Porpiglia Matteo Manfredi Cristian Fiori Alessandro Antonelli Alessandro Tafuri Pierluigi Bove Carlo Terrone Marco Borghesi Elisabetta Costantini Ester Iliano Emanuele Montanari Luca Boeri Giorgio Ivan Russo Massimo Madonia Alessandro Tedde Alessandro Veccia Claudio Simeone Giovanni Liguori Carlo Trombetta Eugenio Brunocilla Riccardo Schiavina Fabrizio Dal Moro Marco Racioppi Mihai Dorin Vartolomei Nicola Longo Lorenzo Spirito Felice Crocetto Francesco Cantiello Rocco Damiano Savino M. Di Stasi Michele Marchioni Luigi Schips Paolo Parma Luca Carmignani Andrea Conti Francesco Soria Paolo Gontero Biagio Barone Federico Deho Emanuele Zaffuto Rocco Papalia Roberto M. Scarpa Vincenzo Pagliarulo Giuseppe Lucarelli Pasquale Ditonno Francesco Maria Gerardo Botticelli Gennaro Musi Michele Catellani Ottavio de Cobelli |
| author_sort | Matteo Ferro |
| collection | DOAJ |
| description | Background: To investigate the impact of COVID-19 outbreak on the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). Methods: A retrospective analysis was performed using an Italian multi-institutional database of TURBT patients with high-risk urothelial NMIBC between January 2019 and February 2021, followed by Re-TURBT and/or adjuvant intravesical BCG. Results: A total of 2591 patients from 27 institutions with primary TURBT were included. Of these, 1534 (59.2%) and 1056 (40.8%) underwent TURBT before and during the COVID-19 outbreak, respectively. Time between diagnosis and TURBT was significantly longer during the COVID-19 period (65 vs. 52 days, <i>p</i> = 0.002). One thousand and sixty-six patients (41.1%) received Re-TURBT, 604 (56.7%) during the pre-COVID-19. The median time to secondary resection was significantly longer during the COVID-19 period (55 vs. 48 days, <i>p</i> < 0.0001). A total of 977 patients underwent adjuvant intravesical therapy after primary or secondary resection, with a similar distribution across the two groups (<i>n</i> = 453, 86% vs. <i>n</i> = 388, 86.2%). However, the proportion of the patients who underwent maintenance significantly differed (79.5% vs. 60.4%, <i>p</i> < 0.0001). Conclusions: The COVID-19 pandemic represented an unprecedented challenge to our health system. Our study did not show significant differences in TURBT quality. However, a delay in treatment schedule and disease management was observed. Investigation of the oncological impacts of those differences should be advocated. |
| first_indexed | 2024-03-09T04:38:22Z |
| format | Article |
| id | doaj.art-b269446779574f8987de160ab9c969df |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:38:22Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b269446779574f8987de160ab9c969df2023-12-03T13:24:59ZengMDPI AGCancers2072-66942021-10-011321527610.3390/cancers13215276The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort AnalysisMatteo Ferro0Francesco Del Giudice1Giuseppe Carrieri2Gian Maria Busetto3Luigi Cormio4Rodolfo Hurle5Roberto Contieri6Davide Arcaniolo7Alessandro Sciarra8Martina Maggi9Francesco Porpiglia10Matteo Manfredi11Cristian Fiori12Alessandro Antonelli13Alessandro Tafuri14Pierluigi Bove15Carlo Terrone16Marco Borghesi17Elisabetta Costantini18Ester Iliano19Emanuele Montanari20Luca Boeri21Giorgio Ivan Russo22Massimo Madonia23Alessandro Tedde24Alessandro Veccia25Claudio Simeone26Giovanni Liguori27Carlo Trombetta28Eugenio Brunocilla29Riccardo Schiavina30Fabrizio Dal Moro31Marco Racioppi32Mihai Dorin Vartolomei33Nicola Longo34Lorenzo Spirito35Felice Crocetto36Francesco Cantiello37Rocco Damiano38Savino M. Di Stasi39Michele Marchioni40Luigi Schips41Paolo Parma42Luca Carmignani43Andrea Conti44Francesco Soria45Paolo Gontero46Biagio Barone47Federico Deho48Emanuele Zaffuto49Rocco Papalia50Roberto M. Scarpa51Vincenzo Pagliarulo52Giuseppe Lucarelli53Pasquale Ditonno54Francesco Maria Gerardo Botticelli55Gennaro Musi56Michele Catellani57Ottavio de Cobelli58Department of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, ItalyDepartment of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyUrology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyUrology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyUrology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyDepartment of Urology, Humanitas Research Hospital, IRCCS, 20089 Milan, ItalyDepartment of Urology, Humanitas Research Hospital, IRCCS, 20089 Milan, ItalyUnit of Urology, Luigi Vanvitelli University of Campania, 80138 Naples, ItalyDepartment of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, ItalyDepartment of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, ItalyDepartment of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, ItalyDepartment of Urology, Ospedale Civile Maggiore, Polo Chirurgico Confortini, University of Verona, 37126 Verona, ItalyDepartment of Urology, Ospedale Civile Maggiore, Polo Chirurgico Confortini, University of Verona, 37126 Verona, ItalyDepartment of Urology, San Carlo di Nancy Hospital, Via Aurelia 275, 00165 Rome, ItalyDepartment of Urology, Policlinico San Martino Hospital, University of Genoa, 16132 Genova, ItalyDepartment of Urology, Policlinico San Martino Hospital, University of Genoa, 16132 Genova, ItalyAndrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, ItalyAndrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, ItalyUrology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyUrology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Urology, University of Catania, 95124 Catania, ItalyUrologic Clinic, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, ItalyUrologic Clinic, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, ItalyDivision of Urology, VCU Health System, Richmond, VA 23298, USAUrology Unit, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 25121 Brescia, ItalyDepartment of Urology, ASUITS, University of Trieste, 34149 Trieste, ItalyDepartment of Urology, ASUITS, University of Trieste, 34149 Trieste, ItalyDepartment of Urology, University of Bologna, S-Orsola-Malpighi Hospital, 40138 Bologna, ItalyDepartment of Urology, University of Bologna, S-Orsola-Malpighi Hospital, 40138 Bologna, ItalyUrology Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, ItalyUrology Clinic, A. Gemelli Hospital Foundation, Catholic University of the Sacred Heart, IRCCS, 00168 Rome, ItalyUrology Department, Medical University of Vienna, A-1090 Vienna, AustriaUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Urology, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Surgery and Experimental Medicine, Tor Vergata University, 00133 Rome, ItalyDepartment of Medical, Oral and Biotechnological Sciences, Urology Unit, “SS. Annunziata” Hospital, G. d’Annunzio University of Chieti, 66100 Chieti, ItalyDepartment of Medical, Oral and Biotechnological Sciences, Urology Unit, “SS. Annunziata” Hospital, G. d’Annunzio University of Chieti, 66100 Chieti, ItalyUrology Unit, Ospedale San Carlo Poma, 46100 Mantova, ItalyDepartment of Urology, San Donato Policlinic Hospital, 20094 Milan, ItalyDepartment of Urology, San Donato Policlinic Hospital, 20094 Milan, ItalyDepartment of Surgical Sciences, Division of Urology, San Giovanni Battista Hospital, University of Studies of Torino, 10121 Turin, ItalyDepartment of Surgical Sciences, Division of Urology, San Giovanni Battista Hospital, University of Studies of Torino, 10121 Turin, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUnit of Urology, ASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, ItalyUnit of Urology, ASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, ItalyDepartment of Urology, Campus Biomedico University Hospital, 00198 Rome, ItalyDepartment of Urology, Campus Biomedico University Hospital, 00198 Rome, ItalyUrology Unit, Ospedale Vito Fazzi, 73100 Lecce, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyDepartment of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, ItalyDepartment of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, ItalyDepartment of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, ItalyDepartment of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, ItalyBackground: To investigate the impact of COVID-19 outbreak on the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). Methods: A retrospective analysis was performed using an Italian multi-institutional database of TURBT patients with high-risk urothelial NMIBC between January 2019 and February 2021, followed by Re-TURBT and/or adjuvant intravesical BCG. Results: A total of 2591 patients from 27 institutions with primary TURBT were included. Of these, 1534 (59.2%) and 1056 (40.8%) underwent TURBT before and during the COVID-19 outbreak, respectively. Time between diagnosis and TURBT was significantly longer during the COVID-19 period (65 vs. 52 days, <i>p</i> = 0.002). One thousand and sixty-six patients (41.1%) received Re-TURBT, 604 (56.7%) during the pre-COVID-19. The median time to secondary resection was significantly longer during the COVID-19 period (55 vs. 48 days, <i>p</i> < 0.0001). A total of 977 patients underwent adjuvant intravesical therapy after primary or secondary resection, with a similar distribution across the two groups (<i>n</i> = 453, 86% vs. <i>n</i> = 388, 86.2%). However, the proportion of the patients who underwent maintenance significantly differed (79.5% vs. 60.4%, <i>p</i> < 0.0001). Conclusions: The COVID-19 pandemic represented an unprecedented challenge to our health system. Our study did not show significant differences in TURBT quality. However, a delay in treatment schedule and disease management was observed. Investigation of the oncological impacts of those differences should be advocated.https://www.mdpi.com/2072-6694/13/21/5276bladder cancerSARS-CoV-2intravesical BCGtrans-urethral resection of bladder tumorRe-TURBT |
| spellingShingle | Matteo Ferro Francesco Del Giudice Giuseppe Carrieri Gian Maria Busetto Luigi Cormio Rodolfo Hurle Roberto Contieri Davide Arcaniolo Alessandro Sciarra Martina Maggi Francesco Porpiglia Matteo Manfredi Cristian Fiori Alessandro Antonelli Alessandro Tafuri Pierluigi Bove Carlo Terrone Marco Borghesi Elisabetta Costantini Ester Iliano Emanuele Montanari Luca Boeri Giorgio Ivan Russo Massimo Madonia Alessandro Tedde Alessandro Veccia Claudio Simeone Giovanni Liguori Carlo Trombetta Eugenio Brunocilla Riccardo Schiavina Fabrizio Dal Moro Marco Racioppi Mihai Dorin Vartolomei Nicola Longo Lorenzo Spirito Felice Crocetto Francesco Cantiello Rocco Damiano Savino M. Di Stasi Michele Marchioni Luigi Schips Paolo Parma Luca Carmignani Andrea Conti Francesco Soria Paolo Gontero Biagio Barone Federico Deho Emanuele Zaffuto Rocco Papalia Roberto M. Scarpa Vincenzo Pagliarulo Giuseppe Lucarelli Pasquale Ditonno Francesco Maria Gerardo Botticelli Gennaro Musi Michele Catellani Ottavio de Cobelli The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis Cancers bladder cancer SARS-CoV-2 intravesical BCG trans-urethral resection of bladder tumor Re-TURBT |
| title | The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis |
| title_full | The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis |
| title_fullStr | The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis |
| title_full_unstemmed | The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis |
| title_short | The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis |
| title_sort | impact of sars cov 2 pandemic on time to primary secondary resection and adjuvant intravesical therapy in patients with high risk non muscle invasive bladder cancer a retrospective multi institutional cohort analysis |
| topic | bladder cancer SARS-CoV-2 intravesical BCG trans-urethral resection of bladder tumor Re-TURBT |
| url | https://www.mdpi.com/2072-6694/13/21/5276 |
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impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT giuseppecarrieri impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT gianmariabusetto impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT luigicormio impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT rodolfohurle impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT robertocontieri impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT davidearcaniolo impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT alessandrosciarra impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT martinamaggi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT francescoporpiglia impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT matteomanfredi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT cristianfiori impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT alessandroantonelli impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT alessandrotafuri impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT pierluigibove impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT carloterrone impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT marcoborghesi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT elisabettacostantini impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT esteriliano impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT emanuelemontanari impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT lucaboeri impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT giorgioivanrusso impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT massimomadonia impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT alessandrotedde impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT alessandroveccia impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT claudiosimeone impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT giovanniliguori impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT carlotrombetta impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT eugeniobrunocilla impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT riccardoschiavina impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT fabriziodalmoro impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT marcoracioppi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT mihaidorinvartolomei impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT nicolalongo impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT lorenzospirito impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT felicecrocetto impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT francescocantiello impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT roccodamiano impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT savinomdistasi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT michelemarchioni impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT luigischips impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT paoloparma impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT lucacarmignani impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT andreaconti impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT francescosoria impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT paologontero impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT biagiobarone impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT federicodeho impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT emanuelezaffuto impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT roccopapalia impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT robertomscarpa impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT vincenzopagliarulo impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT giuseppelucarelli impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT pasqualeditonno impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT francescomariagerardobotticelli impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT gennaromusi impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT michelecatellani impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis AT ottaviodecobelli impactofsarscov2pandemicontimetoprimarysecondaryresectionandadjuvantintravesicaltherapyinpatientswithhighrisknonmuscleinvasivebladdercanceraretrospectivemultiinstitutionalcohortanalysis |