SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure

SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure

Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether the novel compound SUL-151 with mitoprotective...

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Bibliographic Details
Main Authors: Lei Wang, Charlotte E. Pelgrim, Daniël H. Swart, Guido Krenning, Adrianus C. van der Graaf, Aletta D. Kraneveld, Thea Leusink-Muis, Ingrid van Ark, Johan Garssen, Gert Folkerts, Saskia Braber
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
COPD
inflammation
oxidative stress
budesonide
neutrophils
SUL compound
Online Access:https://www.mdpi.com/1422-0067/22/9/4991

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