Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking.
Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators that influence the development and extent of an inflammatory response. Newly synthesized and/or preformed stored cytokines and other inflammatory mediators are released upon stimulation, the timing and volume of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00538/full |
| _version_ | 1818130909410361344 |
|---|---|
| author | Rachael Zoe Murray Jennifer L Stow |
| author_facet | Rachael Zoe Murray Jennifer L Stow |
| author_sort | Rachael Zoe Murray |
| collection | DOAJ |
| description | Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators that influence the development and extent of an inflammatory response. Newly synthesized and/or preformed stored cytokines and other inflammatory mediators are released upon stimulation, the timing and volume of which is highly regulated. To finely tune this process secretion is regulated at many levels; at the level of transcription and translation and posttranslationally at the ER, Golgi and at or near the cell surface. Here we discuss recent advances in deciphering these cytokine pathways in macrophages, focusing on recent discoveries regarding the cellular machinery and mechanisms implicated in the synthesis, trafficking and secretion of cytokines. The specific roles of trafficking machinery including chaperones, GTPases, cytoskeletal proteins and SNARE membrane fusion proteins will be discussed. |
| first_indexed | 2024-12-11T08:12:32Z |
| format | Article |
| id | doaj.art-b26a01c0ef594927b703590f86065d1d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T08:12:32Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b26a01c0ef594927b703590f86065d1d2022-12-22T01:14:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-10-01510.3389/fimmu.2014.00538118065Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking.Rachael Zoe Murray0Jennifer L Stow1Queensland University of TechnologyThe University of QueenslandMacrophages have the capacity to rapidly secrete a wide range of inflammatory mediators that influence the development and extent of an inflammatory response. Newly synthesized and/or preformed stored cytokines and other inflammatory mediators are released upon stimulation, the timing and volume of which is highly regulated. To finely tune this process secretion is regulated at many levels; at the level of transcription and translation and posttranslationally at the ER, Golgi and at or near the cell surface. Here we discuss recent advances in deciphering these cytokine pathways in macrophages, focusing on recent discoveries regarding the cellular machinery and mechanisms implicated in the synthesis, trafficking and secretion of cytokines. The specific roles of trafficking machinery including chaperones, GTPases, cytoskeletal proteins and SNARE membrane fusion proteins will be discussed.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00538/fullMacrophagesIL-10TNFil-12IL-6Rabs |
| spellingShingle | Rachael Zoe Murray Jennifer L Stow Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. Frontiers in Immunology Macrophages IL-10 TNF il-12 IL-6 Rabs |
| title | Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. |
| title_full | Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. |
| title_fullStr | Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. |
| title_full_unstemmed | Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. |
| title_short | Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking. |
| title_sort | cytokine secretion in macrophages snares rabs and membrane trafficking |
| topic | Macrophages IL-10 TNF il-12 IL-6 Rabs |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00538/full |
| work_keys_str_mv | AT rachaelzoemurray cytokinesecretioninmacrophagessnaresrabsandmembranetrafficking AT jenniferlstow cytokinesecretioninmacrophagessnaresrabsandmembranetrafficking |