Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia
2015-12-01
|
| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874&tlng=en |
| _version_ | 1798019778379513856 |
|---|---|
| author | Paola Jung Mendaçolli Gabrielli Brianezi Juliano Vilaverde Schmitt Mariângela Esther Alencar Marques Hélio Amante Miot |
| author_facet | Paola Jung Mendaçolli Gabrielli Brianezi Juliano Vilaverde Schmitt Mariângela Esther Alencar Marques Hélio Amante Miot |
| author_sort | Paola Jung Mendaçolli |
| collection | DOAJ |
| description | Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype. |
| first_indexed | 2024-04-11T16:46:26Z |
| format | Article |
| id | doaj.art-b26a21160e6c42d1bac607754b49ac98 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-11T16:46:26Z |
| publishDate | 2015-12-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-b26a21160e6c42d1bac607754b49ac982022-12-22T04:13:33ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962015-12-0190687487810.1590/abd1806-4841.20154076Nuclear morphometry and chromatin textural characteristics of basal cell carcinomaPaola Jung MendaçolliGabrielli BrianeziJuliano Vilaverde SchmittMariângela Esther Alencar MarquesHélio Amante MiotAbstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874&tlng=enCarcinoma, basal cellChromatinKaryometryImage processing, computer-assistedPrognosis |
| spellingShingle | Paola Jung Mendaçolli Gabrielli Brianezi Juliano Vilaverde Schmitt Mariângela Esther Alencar Marques Hélio Amante Miot Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma Anais Brasileiros de Dermatologia Carcinoma, basal cell Chromatin Karyometry Image processing, computer-assisted Prognosis |
| title | Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| title_full | Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| title_fullStr | Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| title_full_unstemmed | Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| title_short | Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| title_sort | nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
| topic | Carcinoma, basal cell Chromatin Karyometry Image processing, computer-assisted Prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874&tlng=en |
| work_keys_str_mv | AT paolajungmendacolli nuclearmorphometryandchromatintexturalcharacteristicsofbasalcellcarcinoma AT gabriellibrianezi nuclearmorphometryandchromatintexturalcharacteristicsofbasalcellcarcinoma AT julianovilaverdeschmitt nuclearmorphometryandchromatintexturalcharacteristicsofbasalcellcarcinoma AT mariangelaestheralencarmarques nuclearmorphometryandchromatintexturalcharacteristicsofbasalcellcarcinoma AT helioamantemiot nuclearmorphometryandchromatintexturalcharacteristicsofbasalcellcarcinoma |