The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
<p>Abstract</p> <p>Background</p> <p>GPR125 belongs to the family of <it>Adhesion </it>G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a <it>Drosophila </it>sequence, DmCG15744...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2008-10-01
|
Series: | BMC Neuroscience |
Online Access: | http://www.biomedcentral.com/1471-2202/9/97 |
_version_ | 1818393583523201024 |
---|---|
author | Fredriksson Robert Chodobski Adam Waller Linn Palha Joana A Marques Fernanda Szmydynger-Chodobska Joanna Hägglund Maria Pickering Chris Lagerström Malin C Schiöth Helgi B |
author_facet | Fredriksson Robert Chodobski Adam Waller Linn Palha Joana A Marques Fernanda Szmydynger-Chodobska Joanna Hägglund Maria Pickering Chris Lagerström Malin C Schiöth Helgi B |
author_sort | Fredriksson Robert |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>GPR125 belongs to the family of <it>Adhesion </it>G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a <it>Drosophila </it>sequence, DmCG15744, which shares a common ancestor with the entire Group III of <it>Adhesio</it>n GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125.</p> <p>Results</p> <p>We found specific expression of GPR125 in cells of the choroid plexus using <it>in situ </it>hybridization and protein-specific antibodies and combined <it>in situ</it>/immunohistochemistry co-localization using cytokeratin, a marker specific for epithelial cells. Induction of inflammation by LPS did not change GPR125 expression. However, GPR125 expression was transiently increased (almost 2-fold) at 4 h after traumatic brain injury (TBI) followed by a decrease (approximately 4-fold) from 2 days onwards in the choroid plexus as well as increased expression (2-fold) in the hippocampus that was delayed until 1 day after injury.</p> <p>Conclusion</p> <p>These findings suggest that GPR125 plays a functional role in choroidal and hippocampal response to injury.</p> |
first_indexed | 2024-12-14T05:47:37Z |
format | Article |
id | doaj.art-b26a7221d45f446a8cfb6ca0b977e093 |
institution | Directory Open Access Journal |
issn | 1471-2202 |
language | English |
last_indexed | 2024-12-14T05:47:37Z |
publishDate | 2008-10-01 |
publisher | BMC |
record_format | Article |
series | BMC Neuroscience |
spelling | doaj.art-b26a7221d45f446a8cfb6ca0b977e0932022-12-21T23:14:49ZengBMCBMC Neuroscience1471-22022008-10-01919710.1186/1471-2202-9-97The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injuryFredriksson RobertChodobski AdamWaller LinnPalha Joana AMarques FernandaSzmydynger-Chodobska JoannaHägglund MariaPickering ChrisLagerström Malin CSchiöth Helgi B<p>Abstract</p> <p>Background</p> <p>GPR125 belongs to the family of <it>Adhesion </it>G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a <it>Drosophila </it>sequence, DmCG15744, which shares a common ancestor with the entire Group III of <it>Adhesio</it>n GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125.</p> <p>Results</p> <p>We found specific expression of GPR125 in cells of the choroid plexus using <it>in situ </it>hybridization and protein-specific antibodies and combined <it>in situ</it>/immunohistochemistry co-localization using cytokeratin, a marker specific for epithelial cells. Induction of inflammation by LPS did not change GPR125 expression. However, GPR125 expression was transiently increased (almost 2-fold) at 4 h after traumatic brain injury (TBI) followed by a decrease (approximately 4-fold) from 2 days onwards in the choroid plexus as well as increased expression (2-fold) in the hippocampus that was delayed until 1 day after injury.</p> <p>Conclusion</p> <p>These findings suggest that GPR125 plays a functional role in choroidal and hippocampal response to injury.</p>http://www.biomedcentral.com/1471-2202/9/97 |
spellingShingle | Fredriksson Robert Chodobski Adam Waller Linn Palha Joana A Marques Fernanda Szmydynger-Chodobska Joanna Hägglund Maria Pickering Chris Lagerström Malin C Schiöth Helgi B The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury BMC Neuroscience |
title | The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
title_full | The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
title_fullStr | The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
title_full_unstemmed | The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
title_short | The <it>Adhesion </it>GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
title_sort | it adhesion it gpcr gpr125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
url | http://www.biomedcentral.com/1471-2202/9/97 |
work_keys_str_mv | AT fredrikssonrobert theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT chodobskiadam theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT wallerlinn theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT palhajoanaa theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT marquesfernanda theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT szmydyngerchodobskajoanna theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT hagglundmaria theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT pickeringchris theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT lagerstrommalinc theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT schiothhelgib theitadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT fredrikssonrobert itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT chodobskiadam itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT wallerlinn itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT palhajoanaa itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT marquesfernanda itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT szmydyngerchodobskajoanna itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT hagglundmaria itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT pickeringchris itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT lagerstrommalinc itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury AT schiothhelgib itadhesionitgpcrgpr125isspecificallyexpressedinthechoroidplexusandisupregulatedfollowingbraininjury |