Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study
Transient epileptic amnesia (TEA) is a rare epileptic condition, often confused with transient global amnesia (TGA). In a real-life scenario, differential diagnosis between these two conditions can be hard. In this study we use power spectral analysis empowered by exact Low Resolution Brain Electrom...
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MDPI AG
2020-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/9/613 |
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| author | Jacopo Lanzone Claudio Imperatori Giovanni Assenza Lorenzo Ricci Benedetto Farina Vincenzo Di Lazzaro Mario Tombini |
| author_facet | Jacopo Lanzone Claudio Imperatori Giovanni Assenza Lorenzo Ricci Benedetto Farina Vincenzo Di Lazzaro Mario Tombini |
| author_sort | Jacopo Lanzone |
| collection | DOAJ |
| description | Transient epileptic amnesia (TEA) is a rare epileptic condition, often confused with transient global amnesia (TGA). In a real-life scenario, differential diagnosis between these two conditions can be hard. In this study we use power spectral analysis empowered by exact Low Resolution Brain Electromagnetic Tomography (eLORETA) to evidence the differences between TEA and TGA. Fifteen patients affected by TEA (64.2 ± 5.2 y.o.; 11 female/4 male; 10 left and 5 right temporal epileptic focus) and 15 patients affected by TGA (65.8 ± 7.2 y.o.; 11 females/4 males) were retrospectively identified in our clinical records. All patients recorded EEGs after symptoms offset. EEGs were analyzed with eLORETA to evidence power spectral contrast between the two conditions. We used an inverse problem solution to localize the source of spectral differences. We found a significant increase in beta band power over the affected hemisphere of TEA patients. Significant results corresponded to the uncus and para-hippocampal gyrus, respectively Brodmann’s Areas: 36, 35, 28, 34. We present original evidence of an increase in beta power in the affected hemisphere (AH) of TEA as compared to TGA. These differences involve key areas of the memory network located in the mesial temporal lobe. Spectral asymmetries could be used in the future to recognize cases of amnesia with a high risk of epilepsy. |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T16:32:09Z |
| publishDate | 2020-09-01 |
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| series | Brain Sciences |
| spelling | doaj.art-b26b9ebed5314b9faf91c372ca8248b62023-11-20T12:46:12ZengMDPI AGBrain Sciences2076-34252020-09-0110961310.3390/brainsci10090613Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG StudyJacopo Lanzone0Claudio Imperatori1Giovanni Assenza2Lorenzo Ricci3Benedetto Farina4Vincenzo Di Lazzaro5Mario Tombini6Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyCognitive and Clinical Psychology Laboratory, Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163 Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyCognitive and Clinical Psychology Laboratory, Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163 Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyTransient epileptic amnesia (TEA) is a rare epileptic condition, often confused with transient global amnesia (TGA). In a real-life scenario, differential diagnosis between these two conditions can be hard. In this study we use power spectral analysis empowered by exact Low Resolution Brain Electromagnetic Tomography (eLORETA) to evidence the differences between TEA and TGA. Fifteen patients affected by TEA (64.2 ± 5.2 y.o.; 11 female/4 male; 10 left and 5 right temporal epileptic focus) and 15 patients affected by TGA (65.8 ± 7.2 y.o.; 11 females/4 males) were retrospectively identified in our clinical records. All patients recorded EEGs after symptoms offset. EEGs were analyzed with eLORETA to evidence power spectral contrast between the two conditions. We used an inverse problem solution to localize the source of spectral differences. We found a significant increase in beta band power over the affected hemisphere of TEA patients. Significant results corresponded to the uncus and para-hippocampal gyrus, respectively Brodmann’s Areas: 36, 35, 28, 34. We present original evidence of an increase in beta power in the affected hemisphere (AH) of TEA as compared to TGA. These differences involve key areas of the memory network located in the mesial temporal lobe. Spectral asymmetries could be used in the future to recognize cases of amnesia with a high risk of epilepsy.https://www.mdpi.com/2076-3425/10/9/613qEEGepilepsyTGAtransient epileptic amnesiaEEGLORETA |
| spellingShingle | Jacopo Lanzone Claudio Imperatori Giovanni Assenza Lorenzo Ricci Benedetto Farina Vincenzo Di Lazzaro Mario Tombini Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study Brain Sciences qEEG epilepsy TGA transient epileptic amnesia EEG LORETA |
| title | Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study |
| title_full | Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study |
| title_fullStr | Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study |
| title_full_unstemmed | Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study |
| title_short | Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study |
| title_sort | power spectral differences between transient epileptic and global amnesia an eloreta quantitative eeg study |
| topic | qEEG epilepsy TGA transient epileptic amnesia EEG LORETA |
| url | https://www.mdpi.com/2076-3425/10/9/613 |
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