Effects of 48-hour feed deprivation on acute-phase response in horses
The objective of this study was to evaluate the effect of feed restriction on acute-phase response in horses. Twenty horses were deprived of food for 48 h and others 12 animals (control) had free access to water and hay. They were closely monitored and examined, and blood samples were taken at the...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Goiás
2022-08-01
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| Series: | Ciência Animal Brasileira |
| Online Access: | https://revistas.ufg.br/vet/article/view/72445 |
| _version_ | 1797793122765242368 |
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| author | Paula Alessandra Di Filippo Bárbara Ribeiro Duarte Antônio Peixoto Albernaz Leandro Abreu da Fonseca Inácio Silva Viana Célia Raquel Quirino |
| author_facet | Paula Alessandra Di Filippo Bárbara Ribeiro Duarte Antônio Peixoto Albernaz Leandro Abreu da Fonseca Inácio Silva Viana Célia Raquel Quirino |
| author_sort | Paula Alessandra Di Filippo |
| collection | DOAJ |
| description |
The objective of this study was to evaluate the effect of feed restriction on acute-phase response in horses. Twenty horses were deprived of food for 48 h and others 12 animals (control) had free access to water and hay. They were closely monitored and examined, and blood samples were taken at the beginning (0) of the study and 6, 12, 18, 24, 30, 36, 42 and 48 hours afterward. Data were submitted to two-way analysis of variance with repeated measures and statistical significance was P ≤ 0.05. The horses tolerated feed restriction without serious clinical complications. Feed restriction induced an increase in the acute-phase response by elevating serum concentrations of α2-macroglobulin (24-38 h), ceruloplasmin (36-48 h), α1-antitrypsin (30-48 h), α1-acid glycoprotein (42-48 h) and haptoglobin (42-48 h). Nutrient deprivation raised the levels of circulating cortisol, which acts on the innate immune system, which then induces the acute-phase response. In conclusion, food restriction is a physical stressor for horses, capable of inducing an acute-phase protein reaction, characterized by increased production of α2-macroglobulin, ceruloplasmin, α1-antitrypsin, α1-acid glycoprotein and haptoglobin.
Keywords: Equine; Feed restriction; Inflammation; Immune response; Proteins; Stress.The objective of this study was to evaluate the effect of feed restriction on acute-phase response in horses. Twenty horses were deprived of food for 48 h and others 12 animals (control) had free access to water and hay. They were closely monitored and examined, and blood samples were taken at the beginning (0) of the study and 6, 12, 18, 24, 30, 36, 42 and 48 hours afterward. Data were submitted to two-way analysis of variance with repeated measures and statistical significance was P ≤ 0.05. The horses tolerated feed restriction without serious clinical complications. Feed restriction induced an increase in the acute-phase response by elevating serum concentrations of α2-macroglobulin (24-38 h), ceruloplasmin (36-48 h), α1-antitrypsin (30-48 h), α1-acid glycoprotein (42-48 h) and haptoglobin (42-48 h). Nutrient deprivation raised the levels of circulating cortisol, which acts on the innate immune system, which then induces the acute-phase response. In conclusion, food restriction is a physical stressor for horses, capable of inducing an acute-phase protein reaction, characterized by increased production of α2-macroglobulin, ceruloplasmin, α1-antitrypsin, α1-acid glycoprotein and haptoglobin.
Keywords: Equine; Feed restriction; Inflammation; Immune response; Proteins; Stress.
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| first_indexed | 2024-03-13T02:42:44Z |
| format | Article |
| id | doaj.art-b26ec5f747fb40f3a74f62b8cc04b6b4 |
| institution | Directory Open Access Journal |
| issn | 1518-2797 1809-6891 |
| language | English |
| last_indexed | 2024-03-13T02:42:44Z |
| publishDate | 2022-08-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj.art-b26ec5f747fb40f3a74f62b8cc04b6b42023-06-28T21:06:08ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912022-08-0123Effects of 48-hour feed deprivation on acute-phase response in horsesPaula Alessandra Di Filippo0Bárbara Ribeiro Duarte1Antônio Peixoto Albernaz2Leandro Abreu da Fonseca 3Inácio Silva Viana4Célia Raquel Quirino 5Universidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, BrasilUniversidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, BrasilUniversidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, BrasilUniversidade Federal de Viçosa (UFV), Viçosa, Minas Gerais, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, BrasilUniversidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil The objective of this study was to evaluate the effect of feed restriction on acute-phase response in horses. Twenty horses were deprived of food for 48 h and others 12 animals (control) had free access to water and hay. They were closely monitored and examined, and blood samples were taken at the beginning (0) of the study and 6, 12, 18, 24, 30, 36, 42 and 48 hours afterward. Data were submitted to two-way analysis of variance with repeated measures and statistical significance was P ≤ 0.05. The horses tolerated feed restriction without serious clinical complications. Feed restriction induced an increase in the acute-phase response by elevating serum concentrations of α2-macroglobulin (24-38 h), ceruloplasmin (36-48 h), α1-antitrypsin (30-48 h), α1-acid glycoprotein (42-48 h) and haptoglobin (42-48 h). Nutrient deprivation raised the levels of circulating cortisol, which acts on the innate immune system, which then induces the acute-phase response. In conclusion, food restriction is a physical stressor for horses, capable of inducing an acute-phase protein reaction, characterized by increased production of α2-macroglobulin, ceruloplasmin, α1-antitrypsin, α1-acid glycoprotein and haptoglobin. Keywords: Equine; Feed restriction; Inflammation; Immune response; Proteins; Stress.The objective of this study was to evaluate the effect of feed restriction on acute-phase response in horses. Twenty horses were deprived of food for 48 h and others 12 animals (control) had free access to water and hay. They were closely monitored and examined, and blood samples were taken at the beginning (0) of the study and 6, 12, 18, 24, 30, 36, 42 and 48 hours afterward. Data were submitted to two-way analysis of variance with repeated measures and statistical significance was P ≤ 0.05. The horses tolerated feed restriction without serious clinical complications. Feed restriction induced an increase in the acute-phase response by elevating serum concentrations of α2-macroglobulin (24-38 h), ceruloplasmin (36-48 h), α1-antitrypsin (30-48 h), α1-acid glycoprotein (42-48 h) and haptoglobin (42-48 h). Nutrient deprivation raised the levels of circulating cortisol, which acts on the innate immune system, which then induces the acute-phase response. In conclusion, food restriction is a physical stressor for horses, capable of inducing an acute-phase protein reaction, characterized by increased production of α2-macroglobulin, ceruloplasmin, α1-antitrypsin, α1-acid glycoprotein and haptoglobin. Keywords: Equine; Feed restriction; Inflammation; Immune response; Proteins; Stress. https://revistas.ufg.br/vet/article/view/72445 |
| spellingShingle | Paula Alessandra Di Filippo Bárbara Ribeiro Duarte Antônio Peixoto Albernaz Leandro Abreu da Fonseca Inácio Silva Viana Célia Raquel Quirino Effects of 48-hour feed deprivation on acute-phase response in horses Ciência Animal Brasileira |
| title | Effects of 48-hour feed deprivation on acute-phase response in horses |
| title_full | Effects of 48-hour feed deprivation on acute-phase response in horses |
| title_fullStr | Effects of 48-hour feed deprivation on acute-phase response in horses |
| title_full_unstemmed | Effects of 48-hour feed deprivation on acute-phase response in horses |
| title_short | Effects of 48-hour feed deprivation on acute-phase response in horses |
| title_sort | effects of 48 hour feed deprivation on acute phase response in horses |
| url | https://revistas.ufg.br/vet/article/view/72445 |
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