Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient
Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture. Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to help clinical practice and establish safe volumes and amoun...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-06-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-290-en.html |
| _version_ | 1828169978113687552 |
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| author | Rebecca Parr Hal Robinson Gary Cameron Gillian Broadbent Keith Charlton Heather Wallace Thomas Engelhardt |
| author_facet | Rebecca Parr Hal Robinson Gary Cameron Gillian Broadbent Keith Charlton Heather Wallace Thomas Engelhardt |
| author_sort | Rebecca Parr |
| collection | DOAJ |
| description | Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture.
Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to help clinical practice and establish safe volumes and amounts of local anesthetics.
Methods: Ten patients aged between 53 and 87 years, who underwent hemiarthroplasty following femoral neck fracture were recruited into this study. A fixed volume (40 mL) of 0.25% levobupivacaine was injected before the induction of anesthesia using ultrasound guidance. Venous blood samples were obtained at 0, 10, 20, 30, 45, 60, 75, 90, and 120 min time points and analyzed using mass spectrometry.
Results: The median (interquartile range) maximum observed plasma concentration (Cmax) of levobupivacaine was 0.48 (0.45-0.61) µg/mL, with the time to reach Cmax (tmax) of 38 minutes (30–105) after administration, a half-life of 2.8 h (1.65–5.8), and clearance rate of 0.72 L/min (0.36–1.26). The fixed volume (40 mL) of 0.25% levobupivacaine FICB did not exceed the recognized toxic threshold in adults (2.6 µg/mL).
Conclusion: The data described here indicate a similar levobupivacaine PK profile for older patients undergoing FICB for hip arthroplasty compared with the levobupivacaine PK profile for the general population. |
| first_indexed | 2024-04-12T03:02:08Z |
| format | Article |
| id | doaj.art-b26f43c55e9948bd8f75815209f9fa05 |
| institution | Directory Open Access Journal |
| issn | 2423-4494 |
| language | English |
| last_indexed | 2024-04-12T03:02:08Z |
| publishDate | 2020-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-b26f43c55e9948bd8f75815209f9fa052022-12-22T03:50:39ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942020-06-0162151156Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older PatientRebecca Parr0Hal Robinson1Gary Cameron2Gillian Broadbent3Keith Charlton4Heather Wallace5Thomas Engelhardt6 Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK. Department of Anesthesia, Royal Aberdeen Children’s Hospital, Westburn Rd, Foresterhill, Aberdeen, UK. The Rowett Institute, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK. Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK. Scotia Biologics Ltd., Polwarth Building, Cornhill Rd, Aberdeen, UK. Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK. Department of Anesthesia, Royal Aberdeen Children’s Hospital, Westburn Rd, Foresterhill, Aberdeen, UK. Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture. Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to help clinical practice and establish safe volumes and amounts of local anesthetics. Methods: Ten patients aged between 53 and 87 years, who underwent hemiarthroplasty following femoral neck fracture were recruited into this study. A fixed volume (40 mL) of 0.25% levobupivacaine was injected before the induction of anesthesia using ultrasound guidance. Venous blood samples were obtained at 0, 10, 20, 30, 45, 60, 75, 90, and 120 min time points and analyzed using mass spectrometry. Results: The median (interquartile range) maximum observed plasma concentration (Cmax) of levobupivacaine was 0.48 (0.45-0.61) µg/mL, with the time to reach Cmax (tmax) of 38 minutes (30–105) after administration, a half-life of 2.8 h (1.65–5.8), and clearance rate of 0.72 L/min (0.36–1.26). The fixed volume (40 mL) of 0.25% levobupivacaine FICB did not exceed the recognized toxic threshold in adults (2.6 µg/mL). Conclusion: The data described here indicate a similar levobupivacaine PK profile for older patients undergoing FICB for hip arthroplasty compared with the levobupivacaine PK profile for the general population.http://pbr.mazums.ac.ir/article-1-290-en.htmlpharmacokineticslevobupivacainelocal anesthetic systemic toxicity (last)liquid chromatography with tandem mass spectrometry (lc-ms/ms) |
| spellingShingle | Rebecca Parr Hal Robinson Gary Cameron Gillian Broadbent Keith Charlton Heather Wallace Thomas Engelhardt Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient Pharmaceutical and Biomedical Research pharmacokinetics levobupivacaine local anesthetic systemic toxicity (last) liquid chromatography with tandem mass spectrometry (lc-ms/ms) |
| title | Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient |
| title_full | Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient |
| title_fullStr | Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient |
| title_full_unstemmed | Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient |
| title_short | Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient |
| title_sort | pharmacokinetic profile of plasma levobupivacaine following fascia iliaca compartment block for proximal femoral fracture in older patient |
| topic | pharmacokinetics levobupivacaine local anesthetic systemic toxicity (last) liquid chromatography with tandem mass spectrometry (lc-ms/ms) |
| url | http://pbr.mazums.ac.ir/article-1-290-en.html |
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