Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients
On 27 February 2021, the Food and Drug Administration(FDA) authorized the administration of the adenovirus-based Ad26.COV2-S vaccine (J&J-Janssen) for the prevention of COVID-19, a viral pandemic that, to date, has killed more than 5.5 million people. Performed during the early phase of the COVI...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/8/5/199 |
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| author | Davide Negroni Serena Carriero Ilaria Passarella Agnese Siani Pierpaolo Biondetti Antonio Pizzolante Luca Saba Giuseppe Guzzardi |
| author_facet | Davide Negroni Serena Carriero Ilaria Passarella Agnese Siani Pierpaolo Biondetti Antonio Pizzolante Luca Saba Giuseppe Guzzardi |
| author_sort | Davide Negroni |
| collection | DOAJ |
| description | On 27 February 2021, the Food and Drug Administration(FDA) authorized the administration of the adenovirus-based Ad26.COV2-S vaccine (J&J-Janssen) for the prevention of COVID-19, a viral pandemic that, to date, has killed more than 5.5 million people. Performed during the early phase of the COVID-19 4th wave, this retrospective observational study aims to report the computerized tomography (CT) findings and intensive care unit admission rates of Ad26.COV2-S-vaccinated vs. unvaccinated COVID-19 patients. From the 1st to the 23rd of December 2021, all confirmed COVID-19 patients that had been subjected to chest non-contrast CT scan analysis were enrolled in the study. These were divided into Ad26.COV2.S-vaccinated (group 1) and unvaccinated patients (group 2). The RSNA severity score was calculated for each patient and correlated to CT findings and type of admission to a healthcare setting after CT—i.e., home care, ordinary hospitalization, sub-intensive care, and intensive care. Descriptive and inference statistical analyses were performed by comparing the data from the two groups. Data from a total of 71 patients were collected: 10 patients in group 1 (4M, 6F, mean age 63.5 years, SD ± 4.2) and 61 patients in group 2 (32M, 29F, mean age 64.7 years, SD ± 3.7). Statistical analysis showed lower values of RSNA severity in group 1 compared to group 2 (mean value 14.1 vs. 15.7, <i>p</i> = 0.009, respectively). Furthermore, vaccinated patients were less frequently admitted to both sub-intensive and high-intensive care units than group 2, with an odds ratio of 0.45 [95%CI (0.01; 3.92)]. Ad26.COV2.S vaccination protects from severe COVID-19 based on CT severity scores. As a result, Ad26.COV2.S-vaccinated COVID-19 patients are more frequently admitted to home in comparison with unvaccinated patients. |
| first_indexed | 2024-03-09T19:26:09Z |
| format | Article |
| id | doaj.art-b27061b86526436e8ad9148fb07a7cd8 |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-09T19:26:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-b27061b86526436e8ad9148fb07a7cd82023-11-24T02:56:28ZengMDPI AGTomography2379-13812379-139X2022-09-01852403241010.3390/tomography8050199Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 PatientsDavide Negroni0Serena Carriero1Ilaria Passarella2Agnese Siani3Pierpaolo Biondetti4Antonio Pizzolante5Luca Saba6Giuseppe Guzzardi7Department of Radiology, University of Piemonte Orientale, Piedmont, 28100 Novara, ItalyDepartment of Radiology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartement of Internal Medicine, ASST Ovest Milanese Ospedale Fornaroli, 20013 Magenta, ItalyDepartment of Radiology, University of Piemonte Orientale, Piedmont, 28100 Novara, ItalyDepartment of Radiology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Radiology, University of Piemonte Orientale, Piedmont, 28100 Novara, ItalyDepartment of Radiology, Azienda Ospedaliero Universitaria Cagliari, 09124 Polo di Monserrato, ItalyDepartment of Radiology, University of Piemonte Orientale, Piedmont, 28100 Novara, ItalyOn 27 February 2021, the Food and Drug Administration(FDA) authorized the administration of the adenovirus-based Ad26.COV2-S vaccine (J&J-Janssen) for the prevention of COVID-19, a viral pandemic that, to date, has killed more than 5.5 million people. Performed during the early phase of the COVID-19 4th wave, this retrospective observational study aims to report the computerized tomography (CT) findings and intensive care unit admission rates of Ad26.COV2-S-vaccinated vs. unvaccinated COVID-19 patients. From the 1st to the 23rd of December 2021, all confirmed COVID-19 patients that had been subjected to chest non-contrast CT scan analysis were enrolled in the study. These were divided into Ad26.COV2.S-vaccinated (group 1) and unvaccinated patients (group 2). The RSNA severity score was calculated for each patient and correlated to CT findings and type of admission to a healthcare setting after CT—i.e., home care, ordinary hospitalization, sub-intensive care, and intensive care. Descriptive and inference statistical analyses were performed by comparing the data from the two groups. Data from a total of 71 patients were collected: 10 patients in group 1 (4M, 6F, mean age 63.5 years, SD ± 4.2) and 61 patients in group 2 (32M, 29F, mean age 64.7 years, SD ± 3.7). Statistical analysis showed lower values of RSNA severity in group 1 compared to group 2 (mean value 14.1 vs. 15.7, <i>p</i> = 0.009, respectively). Furthermore, vaccinated patients were less frequently admitted to both sub-intensive and high-intensive care units than group 2, with an odds ratio of 0.45 [95%CI (0.01; 3.92)]. Ad26.COV2.S vaccination protects from severe COVID-19 based on CT severity scores. As a result, Ad26.COV2.S-vaccinated COVID-19 patients are more frequently admitted to home in comparison with unvaccinated patients.https://www.mdpi.com/2379-139X/8/5/199COV2-S vaccineCOVID-19 diseasecomputerized tomographyRSNA severity |
| spellingShingle | Davide Negroni Serena Carriero Ilaria Passarella Agnese Siani Pierpaolo Biondetti Antonio Pizzolante Luca Saba Giuseppe Guzzardi Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients Tomography COV2-S vaccine COVID-19 disease computerized tomography RSNA severity |
| title | Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients |
| title_full | Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients |
| title_fullStr | Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients |
| title_full_unstemmed | Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients |
| title_short | Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients |
| title_sort | preliminary analysis of the effects of ad26 cov2 s vaccination on ct findings and high intensive care admission rates of covid 19 patients |
| topic | COV2-S vaccine COVID-19 disease computerized tomography RSNA severity |
| url | https://www.mdpi.com/2379-139X/8/5/199 |
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