High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update
This updated systematic review and meta-analysis of randomized and observational studies published up to April 2023 assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adult...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Vaccine: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590136223000682 |
| _version_ | 1797752943861039104 |
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| author | Jason K.H. Lee Gary K.L. Lam J. Kevin Yin Matthew M. Loiacono Sandrine I. Samson |
| author_facet | Jason K.H. Lee Gary K.L. Lam J. Kevin Yin Matthew M. Loiacono Sandrine I. Samson |
| author_sort | Jason K.H. Lee |
| collection | DOAJ |
| description | This updated systematic review and meta-analysis of randomized and observational studies published up to April 2023 assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (≥65 years).The analysis included studies conducted over 12 influenza seasons (2009/2010 to 2019/2020, 2021/2022), including over 45 million individuals aged ≥ 65 years, and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-like illness and influenza-related hospitalizations, as well as cardiovascular, cardiorespiratory, and all-cause hospitalizations. Subgroup analyses showed HD-IIV consistently provided better protection than SD-IIV against influenza outcomes across the age range (65+, 75+ 85+ years), and regardless of the predominantly circulating influenza strain and vaccine antigenic match/mismatch.Randomized studies continue to drive high-quality evidence on the effectiveness of high-dose inactivated influenza vaccine relative to SD-IIV against severe influenza outcomes in adults aged ≥ 65 years, supported by observational data. |
| first_indexed | 2024-03-12T17:11:34Z |
| format | Article |
| id | doaj.art-b27162b33b0948658fed84336698e722 |
| institution | Directory Open Access Journal |
| issn | 2590-1362 |
| language | English |
| last_indexed | 2024-03-12T17:11:34Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj.art-b27162b33b0948658fed84336698e7222023-08-06T04:38:14ZengElsevierVaccine: X2590-13622023-08-0114100327High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis updateJason K.H. Lee0Gary K.L. Lam1J. Kevin Yin2Matthew M. Loiacono3Sandrine I. Samson4Leslie Dan School of Pharmacy, University of Toronto, Toronto, ON, Canada; Sanofi, Toronto, ON, Canada; Corresponding author at: Sanofi, Toronto, ON, Canada.Leslie Dan School of Pharmacy, University of Toronto, Toronto, ON, Canada; Sanofi, Toronto, ON, CanadaUniversity of Sydney, Camperdown, NSW, Australia; Sanofi, SingaporeSanofi, Swiftwater, PA, USASanofi, Lyon, FranceThis updated systematic review and meta-analysis of randomized and observational studies published up to April 2023 assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (≥65 years).The analysis included studies conducted over 12 influenza seasons (2009/2010 to 2019/2020, 2021/2022), including over 45 million individuals aged ≥ 65 years, and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-like illness and influenza-related hospitalizations, as well as cardiovascular, cardiorespiratory, and all-cause hospitalizations. Subgroup analyses showed HD-IIV consistently provided better protection than SD-IIV against influenza outcomes across the age range (65+, 75+ 85+ years), and regardless of the predominantly circulating influenza strain and vaccine antigenic match/mismatch.Randomized studies continue to drive high-quality evidence on the effectiveness of high-dose inactivated influenza vaccine relative to SD-IIV against severe influenza outcomes in adults aged ≥ 65 years, supported by observational data.http://www.sciencedirect.com/science/article/pii/S2590136223000682High dose influenza vaccineEffectivenessElderlyHospitalizationInfluenzaMeta-analysis |
| spellingShingle | Jason K.H. Lee Gary K.L. Lam J. Kevin Yin Matthew M. Loiacono Sandrine I. Samson High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update Vaccine: X High dose influenza vaccine Effectiveness Elderly Hospitalization Influenza Meta-analysis |
| title | High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update |
| title_full | High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update |
| title_fullStr | High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update |
| title_full_unstemmed | High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update |
| title_short | High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update |
| title_sort | high dose influenza vaccine in older adults by age and seasonal characteristics systematic review and meta analysis update |
| topic | High dose influenza vaccine Effectiveness Elderly Hospitalization Influenza Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2590136223000682 |
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