Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells
Among known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compo...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/7/216 |
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| author | Lyubov S. Klyushova Natalya V. Kandalintseva Alevtina Y. Grishanova |
| author_facet | Lyubov S. Klyushova Natalya V. Kandalintseva Alevtina Y. Grishanova |
| author_sort | Lyubov S. Klyushova |
| collection | DOAJ |
| description | Among known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compounds for further research on their biological activity in vitro. New sulphur- and selenium-containing analogues of antioxidant potassium phenosan were synthesised. In vitro cytotoxicity and cytostaticity as well as antioxidant activity against H<sub>2</sub>O<sub>2</sub>-induced cytotoxicity to human cell lines (HepG2, Hep-2 and MCF-7) were investigated by high-content analysis. A selenium-containing analogue showed higher biological activity than did a sulphur-containing one. As compared to the activity of potassium phenosan, the selenium-containing analogue had a cell line-dependent antioxidant effect against H<sub>2</sub>O<sub>2</sub>-induced cytotoxicity: comparable in HepG2 cells and greater in Hep-2 cells. The selenium-containing analogue significantly increased the death of MCF-7 cells at concentrations above 50 µM. The sulphur-containing analogue has lower biological activity as compared to potassium phenosan and the selenium-containing analogue. |
| first_indexed | 2024-03-09T04:54:23Z |
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| id | doaj.art-b272e6bee3ca4323b77ff48ca6c97899 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T04:54:23Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-b272e6bee3ca4323b77ff48ca6c978992023-12-03T13:08:01ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-07-014473131314510.3390/cimb44070216Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour CellsLyubov S. Klyushova0Natalya V. Kandalintseva1Alevtina Y. Grishanova2Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, RussiaDepartment of Chemistry, Novosibirsk State Pedagogical University, 28 Vilyuyskaya Str., 630126 Novosibirsk, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, RussiaAmong known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compounds for further research on their biological activity in vitro. New sulphur- and selenium-containing analogues of antioxidant potassium phenosan were synthesised. In vitro cytotoxicity and cytostaticity as well as antioxidant activity against H<sub>2</sub>O<sub>2</sub>-induced cytotoxicity to human cell lines (HepG2, Hep-2 and MCF-7) were investigated by high-content analysis. A selenium-containing analogue showed higher biological activity than did a sulphur-containing one. As compared to the activity of potassium phenosan, the selenium-containing analogue had a cell line-dependent antioxidant effect against H<sub>2</sub>O<sub>2</sub>-induced cytotoxicity: comparable in HepG2 cells and greater in Hep-2 cells. The selenium-containing analogue significantly increased the death of MCF-7 cells at concentrations above 50 µM. The sulphur-containing analogue has lower biological activity as compared to potassium phenosan and the selenium-containing analogue.https://www.mdpi.com/1467-3045/44/7/216phenolic antioxidantspotassium phenosansulphurseleniumin vitro researchcytotoxicity |
| spellingShingle | Lyubov S. Klyushova Natalya V. Kandalintseva Alevtina Y. Grishanova Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells Current Issues in Molecular Biology phenolic antioxidants potassium phenosan sulphur selenium in vitro research cytotoxicity |
| title | Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells |
| title_full | Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells |
| title_fullStr | Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells |
| title_full_unstemmed | Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells |
| title_short | Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H<sub>2</sub>O<sub>2</sub>-Induced Cytotoxicity in Tumour Cells |
| title_sort | antioxidant activity of new sulphur and selenium containing analogues of potassium phenosan against h sub 2 sub o sub 2 sub induced cytotoxicity in tumour cells |
| topic | phenolic antioxidants potassium phenosan sulphur selenium in vitro research cytotoxicity |
| url | https://www.mdpi.com/1467-3045/44/7/216 |
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