Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

Although an increasing number of small interfering RNA (siRNA) therapies are reaching the market, the challenge of efficient extra-hepatic delivery continues to limit their full therapeutic potential. Drug delivery vehicles and hydrophobic conjugates are being used to overcome the delivery bottlenec...

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Bibliographic Details
Main Authors: Hassan H. Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
oligonucleotide therapeutics
siRNAs
protein binding
albumin
drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002986

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http://www.sciencedirect.com/science/article/pii/S2162253123002986

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