| Gaia: | 6-Heteryl-5-methylthieno[2,3-<i>d</i>]pyrimidin-2,4(1<i>H</i>,3<i>H</i>)-diones are of great interest as the promising objects for the search of antibacterials. In this communication, we obtained 6-(imidazo[1,2-<i>a</i>]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione by interaction of 6-(bromoacetyl)-5-methyl-3-phenylthieno[2,3-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione with 2-aminopyridine. The obtained heterocyclic hybrid was further modified by alkylation with 2-chloroarylacetamides. Antimicrobial activity studies for the synthesized compounds using the agar well diffusion method revealed their moderate activity against <i>S. aureus</i>, <i>E. coli</i> and <i>B. subtilis</i>. According to the double dilution assay MIC value results for 6-(imidazo[1,2-<i>a</i>]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dioneagainst <i>P. aeruginosa</i> was less than the value determined for the reference drug streptomycin. The docking study of the synthesized compounds to the active site of TrmD isolated from <i>P. aeruginosa</i> did not show their effective inhibitory activity.
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