The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo
Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reprod...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.575706/full |
| _version_ | 1818544642823553024 |
|---|---|
| author | Yao Chen Weina Yang Xu Shi Chenlu Zhang Ge Song Donghui Huang |
| author_facet | Yao Chen Weina Yang Xu Shi Chenlu Zhang Ge Song Donghui Huang |
| author_sort | Yao Chen |
| collection | DOAJ |
| description | Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation. |
| first_indexed | 2024-12-11T22:51:10Z |
| format | Article |
| id | doaj.art-b2760941174e4c58bf23a5f801bfa537 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T22:51:10Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b2760941174e4c58bf23a5f801bfa5372022-12-22T00:47:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.575706575706The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivoYao Chen0Weina Yang1Xu Shi2Chenlu Zhang3Ge Song4Donghui Huang5Institute of Reproduction Health Research (Institute of Family Planning Research), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Reproduction Health Research (Institute of Family Planning Research), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Reproduction Health Research (Institute of Family Planning Research), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Reproduction Health Research (Institute of Family Planning Research), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaNHC Key Laboratory of Male Reproduction and Genetics, Family Planning Research Institute of Guangdong Province, Guangzhou, ChinaInstitute of Reproduction Health Research (Institute of Family Planning Research), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaMammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation.https://www.frontiersin.org/article/10.3389/fcell.2020.575706/fullprimordial follicleactivationsignaling pathwaysfactorsmechanism |
| spellingShingle | Yao Chen Weina Yang Xu Shi Chenlu Zhang Ge Song Donghui Huang The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo Frontiers in Cell and Developmental Biology primordial follicle activation signaling pathways factors mechanism |
| title | The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo |
| title_full | The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo |
| title_fullStr | The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo |
| title_full_unstemmed | The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo |
| title_short | The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo |
| title_sort | factors and pathways regulating the activation of mammalian primordial follicles in vivo |
| topic | primordial follicle activation signaling pathways factors mechanism |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.575706/full |
| work_keys_str_mv | AT yaochen thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT weinayang thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT xushi thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT chenluzhang thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT gesong thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT donghuihuang thefactorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT yaochen factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT weinayang factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT xushi factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT chenluzhang factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT gesong factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo AT donghuihuang factorsandpathwaysregulatingtheactivationofmammalianprimordialfolliclesinvivo |