THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS
Prognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.The aim is to identify necessary and sufficient amount of immunological parameters for...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2015-06-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/168 |
| _version_ | 1797872922784694272 |
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| author | M. N. Stakheyeva A. P. Serykh S. I. Karas E. A. Perina |
| author_facet | M. N. Stakheyeva A. P. Serykh S. I. Karas E. A. Perina |
| author_sort | M. N. Stakheyeva |
| collection | DOAJ |
| description | Prognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.The aim is to identify necessary and sufficient amount of immunological parameters for accurate classification of breast cancer patients with various outcomes – clinical remission and hematogenous metastases.Material and methods. 36 immunological parameters were studied in 197 breast cancer patients T1–4N0–3M0. The “next neighbor” algorithm was used for identification of informative parameters. Detection of informative parameters complex was carried out by using ADD and DEL methods.Results. Two sets of informative immunological parameters were detected. The ADD method elicited parameters related to T-cell immunity, DEL – to humoral response.Conclusions. The complex of 17–19 immunological parameters characterizing different elements of immune system is necessary for accurate classification of breast cancer patients with different outcomes (presence/absence of hematogenous metastases). |
| first_indexed | 2024-04-10T01:07:49Z |
| format | Article |
| id | doaj.art-b2763d946f384ae49e118d5962de89f0 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:49Z |
| publishDate | 2015-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-b2763d946f384ae49e118d5962de89f02023-03-13T09:58:21ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842015-06-01143303410.20538/1682-0363-2015-3-30-34166THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSISM. N. Stakheyeva0A. P. Serykh1S. I. Karas2E. A. Perina3Томский Научно-исследовательский институт онкологии, ТомскНациональный исследовательский Томский государственный университет, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскPrognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.The aim is to identify necessary and sufficient amount of immunological parameters for accurate classification of breast cancer patients with various outcomes – clinical remission and hematogenous metastases.Material and methods. 36 immunological parameters were studied in 197 breast cancer patients T1–4N0–3M0. The “next neighbor” algorithm was used for identification of informative parameters. Detection of informative parameters complex was carried out by using ADD and DEL methods.Results. Two sets of informative immunological parameters were detected. The ADD method elicited parameters related to T-cell immunity, DEL – to humoral response.Conclusions. The complex of 17–19 immunological parameters characterizing different elements of immune system is necessary for accurate classification of breast cancer patients with different outcomes (presence/absence of hematogenous metastases).https://bulletin.ssmu.ru/jour/article/view/168критерии прогнозарак молочной железыиммунная системаинформативность |
| spellingShingle | M. N. Stakheyeva A. P. Serykh S. I. Karas E. A. Perina THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS Бюллетень сибирской медицины критерии прогноза рак молочной железы иммунная система информативность |
| title | THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS |
| title_full | THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS |
| title_fullStr | THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS |
| title_full_unstemmed | THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS |
| title_short | THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS |
| title_sort | complex of informative immunological parameters for breast cancer outcome prognosis |
| topic | критерии прогноза рак молочной железы иммунная система информативность |
| url | https://bulletin.ssmu.ru/jour/article/view/168 |
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