BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD report...

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Bibliographic Details
Main Authors: Maria Gomes Fernandes, Ruben Dries, Matthias S. Roost, Stefan Semrau, Ana de Melo Bernardo, Richard P. Davis, Ramprasad Ramakrishnan, Karoly Szuhai, Elke Maas, Lieve Umans, Vanesa Abon Escalona, Daniela Salvatori, Dieter Deforce, Wim Van Criekinge, Danny Huylebroeck, Christine Mummery, An Zwijsen, Susana M. Chuva de Sousa Lopes
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003483

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