Polymeric biomaterials in the treatment of posterior segment diseases
Polymeric biomaterials are biological or synthetic substances which can be engineered to interact with biological systems for the diagnosis or treatment of diseases. These biomaterials have immense potential for treating eyes diseases, particularly the retina—a site of many inherited and acquired di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.949543/full |
| _version_ | 1798036997241044992 |
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| author | Ivan Seah Ivan Seah Ivan Seah Charles Ong Zengping Liu Zengping Liu Zengping Liu Xinyi Su Xinyi Su Xinyi Su Xinyi Su |
| author_facet | Ivan Seah Ivan Seah Ivan Seah Charles Ong Zengping Liu Zengping Liu Zengping Liu Xinyi Su Xinyi Su Xinyi Su Xinyi Su |
| author_sort | Ivan Seah |
| collection | DOAJ |
| description | Polymeric biomaterials are biological or synthetic substances which can be engineered to interact with biological systems for the diagnosis or treatment of diseases. These biomaterials have immense potential for treating eyes diseases, particularly the retina—a site of many inherited and acquired diseases. Polymeric biomaterials can be engineered to function both as an endotamponade agent and to prevent intraocular scarring in retinal detachment repair surgeries. They can also be designed as a drug delivery platform for treatment of retinal diseases. Finally, they can be used as scaffolds for cellular products and provide non-viral gene delivery solutions to the retina. This perspective article explains the role of polymeric biomaterials in the treatment of retinal conditions by highlighting recent advances being translated to clinical practice. The article will also identify potential hurdles to clinical translation as future research directions in the field. |
| first_indexed | 2024-04-11T21:20:39Z |
| format | Article |
| id | doaj.art-b27861e58c6843aa88b3a66dfe231725 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T21:20:39Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-b27861e58c6843aa88b3a66dfe2317252022-12-22T04:02:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.949543949543Polymeric biomaterials in the treatment of posterior segment diseasesIvan Seah0Ivan Seah1Ivan Seah2Charles Ong3Zengping Liu4Zengping Liu5Zengping Liu6Xinyi Su7Xinyi Su8Xinyi Su9Xinyi Su10Department of Ophthalmology, National University Hospital, Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeSingapore National Eye Centre (SNEC), Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeSingapore Eye Research Institute (SERI), Singapore, SingaporeDepartment of Ophthalmology, National University Hospital, Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeSingapore Eye Research Institute (SERI), Singapore, SingaporePolymeric biomaterials are biological or synthetic substances which can be engineered to interact with biological systems for the diagnosis or treatment of diseases. These biomaterials have immense potential for treating eyes diseases, particularly the retina—a site of many inherited and acquired diseases. Polymeric biomaterials can be engineered to function both as an endotamponade agent and to prevent intraocular scarring in retinal detachment repair surgeries. They can also be designed as a drug delivery platform for treatment of retinal diseases. Finally, they can be used as scaffolds for cellular products and provide non-viral gene delivery solutions to the retina. This perspective article explains the role of polymeric biomaterials in the treatment of retinal conditions by highlighting recent advances being translated to clinical practice. The article will also identify potential hurdles to clinical translation as future research directions in the field.https://www.frontiersin.org/articles/10.3389/fmed.2022.949543/fullretinal detachmentsdrug delivery systemmacular degenerationspolymerstem cellretinal disease |
| spellingShingle | Ivan Seah Ivan Seah Ivan Seah Charles Ong Zengping Liu Zengping Liu Zengping Liu Xinyi Su Xinyi Su Xinyi Su Xinyi Su Polymeric biomaterials in the treatment of posterior segment diseases Frontiers in Medicine retinal detachments drug delivery system macular degenerations polymer stem cell retinal disease |
| title | Polymeric biomaterials in the treatment of posterior segment diseases |
| title_full | Polymeric biomaterials in the treatment of posterior segment diseases |
| title_fullStr | Polymeric biomaterials in the treatment of posterior segment diseases |
| title_full_unstemmed | Polymeric biomaterials in the treatment of posterior segment diseases |
| title_short | Polymeric biomaterials in the treatment of posterior segment diseases |
| title_sort | polymeric biomaterials in the treatment of posterior segment diseases |
| topic | retinal detachments drug delivery system macular degenerations polymer stem cell retinal disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.949543/full |
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