Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model
Hesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study the lethality, phenotypic deformities,...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021001717 |
| _version_ | 1818612306739724288 |
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| author | Mani Rajasekar |
| author_facet | Mani Rajasekar |
| author_sort | Mani Rajasekar |
| collection | DOAJ |
| description | Hesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study the lethality, phenotypic deformities, and toxicity level of the compound. In that assessment, embryos showed lethality towards 3e at the minimal concentration. It assesses slow heartbeat since the compound loaded, the curvature on the back, upcurved fish, Cardiac chamber bulging, and poor survival rate in 72 h. 3a shows less toxicity more than other compounds. It shows only pericardial edema at higher concentration and 3c induced pericardial edema and upcurved tail at a medium range of the concentration. But both compounds were shown a good survival ratio at the minimal concentration. |
| first_indexed | 2024-12-16T15:44:08Z |
| format | Article |
| id | doaj.art-b2786a27e0dc4753a4d403fb5e11b29a |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-16T15:44:08Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b2786a27e0dc4753a4d403fb5e11b29a2022-12-21T22:25:52ZengElsevierHeliyon2405-84402021-01-0171e06066Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish modelMani Rajasekar0Corresponding author.; Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai 600 119, IndiaHesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study the lethality, phenotypic deformities, and toxicity level of the compound. In that assessment, embryos showed lethality towards 3e at the minimal concentration. It assesses slow heartbeat since the compound loaded, the curvature on the back, upcurved fish, Cardiac chamber bulging, and poor survival rate in 72 h. 3a shows less toxicity more than other compounds. It shows only pericardial edema at higher concentration and 3c induced pericardial edema and upcurved tail at a medium range of the concentration. But both compounds were shown a good survival ratio at the minimal concentration.http://www.sciencedirect.com/science/article/pii/S2405844021001717HesperetinAcid chloridesZebrafishDanio rerioToxicityLethality |
| spellingShingle | Mani Rajasekar Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model Heliyon Hesperetin Acid chlorides Zebrafish Danio rerio Toxicity Lethality |
| title | Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| title_full | Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| title_fullStr | Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| title_full_unstemmed | Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| title_short | Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| title_sort | synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model |
| topic | Hesperetin Acid chlorides Zebrafish Danio rerio Toxicity Lethality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021001717 |
| work_keys_str_mv | AT manirajasekar synthesisandcharacterizationofhesperetinderivativesandtoxicitylevelofthezebrafishmodel |